Targeting Cardiomyocyte Ca²⁺ Homeostasis in Heart Failure

Title:Targeting Cardiomyocyte Ca²⁺ Homeostasis in Heart Failure

Volume: 21 Issue: 4

Author(s): Asmund T. Roe, Michael Frisk and William E. Louch

Affiliation:

Keywords: Cardiac myocytes, calcium homeostasis, heart failure, SR Ca²⁺ ATPase, Na⁺/Ca²⁺ exchanger, ryanodine receptor, t-tubules.

Abstract: Improved treatments for heart failure patients will require the development of novel therapeutic strategies that target basal disease mechanisms. Disrupted cardiomyocyte Ca²⁺ homeostasis is recognized as a major contributor to the heart failure phenotype, as it plays a key role in systolic and diastolic dysfunction, arrhythmogenesis, and hypertrophy and apoptosis signaling. In this review, we outline existing knowledge of the involvement of Ca²⁺ homeostasis in these deficits, and identify four promising targets for therapeutic intervention: the sarcoplasmic reticulum Ca²⁺ ATPase, the Na⁺-Ca²⁺ exchanger, the ryanodine receptor, and t-tubule structure. We discuss experimental data indicating the applicability of these targets that has led to recent and ongoing clinical trials, and suggest future therapeutic approaches.

Cite this article as:

Roe T. Asmund, Frisk Michael and Louch E. William, Targeting Cardiomyocyte Ca²⁺ Homeostasis in Heart Failure, Current Pharmaceutical Design 2015; 21 (4) . https://dx.doi.org/10.2174/138161282104141204124129