Abstract
Nanomedicine is an exponentially growing field, and gold nanoparticles (GNPs) in particular are extensively used in research due to their abilities as anti-cancer drug carriers for chemotherapy and as dose enhancers in radiotherapy. Most GNP research in the past involved a system where GNP localization was in the cytoplasm of the cell. However, it is predicted that therapy response can be enhanced if GNPs can be effectively targeted into the nucleus. With nuclear targeting, there is a possibility in producing additional free radicals in response to irradiation within the nucleus. This can cause more damage to the DNA of cancer cells. In this review article, we discuss the successful NP-based platforms available for nuclear targeting. In addition, we also present the possible mechanisms of nuclear targeting in detail followed by its applications in cancer therapy.
Keywords: Cancer research, Drug delivery, Gold nanoparticles, Nuclear targeting, Radiosensitizer.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:Nuclear Targeting of Gold Nanoparticles for Improved Therapeutics
Volume: 16 Issue: 3
Author(s): Celina J. Yang and Devika B. Chithrani
Affiliation:
Keywords: Cancer research, Drug delivery, Gold nanoparticles, Nuclear targeting, Radiosensitizer.
Abstract: Nanomedicine is an exponentially growing field, and gold nanoparticles (GNPs) in particular are extensively used in research due to their abilities as anti-cancer drug carriers for chemotherapy and as dose enhancers in radiotherapy. Most GNP research in the past involved a system where GNP localization was in the cytoplasm of the cell. However, it is predicted that therapy response can be enhanced if GNPs can be effectively targeted into the nucleus. With nuclear targeting, there is a possibility in producing additional free radicals in response to irradiation within the nucleus. This can cause more damage to the DNA of cancer cells. In this review article, we discuss the successful NP-based platforms available for nuclear targeting. In addition, we also present the possible mechanisms of nuclear targeting in detail followed by its applications in cancer therapy.
Export Options
About this article
Cite this article as:
Yang J. Celina and Chithrani B. Devika, Nuclear Targeting of Gold Nanoparticles for Improved Therapeutics, Current Topics in Medicinal Chemistry 2016; 16 (3) . https://dx.doi.org/10.2174/1568026615666150701115012
DOI https://dx.doi.org/10.2174/1568026615666150701115012 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Multi-Modal Imaging and Cancer Therapy Using Lanthanide Oxide Nanoparticles: Current Status and Perspectives
Current Medicinal Chemistry HPV Cervical Infection and Immunodysregulation: Synergistic Risks for Neoplasia-Review
Current Women`s Health Reviews Sample Preparation Techniques for Mass Spectrometry in Proteomics Using Recently Developed Highly Selective Materials
Current Proteomics Intracellular ROS Generation Mediates Maleimide-induced Cytotoxicity in Leukemia Cells
Anti-Cancer Agents in Medicinal Chemistry The Application of Modified SBA-15 as a Chemosensor
Current Nanomaterials Cellular Functions of Vaults and their Involvement in Multidrug Resistance
Current Drug Targets The Role of Sialylation in Respiratory Viral Infection and Treatment
Current Medicinal Chemistry Exploring Novel Immunological Interventions Using Immunoinfectomics
Anti-Infective Agents Computer-Aided Drug Design of Bioactive Natural Products
Current Topics in Medicinal Chemistry Application of Immunological Techniques (from Vaccination to Final Measurements) in Determination of Pharmaceutical Residues in Environmental Samples
Current Analytical Chemistry Single Molecule Studies of Multiple-Fluorophore Labeled Antibodies. Effect of Homo-FRET on the Number of Photons Available Before Photobleaching
Current Pharmaceutical Biotechnology Clinical Proteomics of Breast Cancer
Current Genomics Innate and Adaptive Immune Responses in Allergic Contact Dermatitis and Autoimmune Skin Diseases
Inflammation & Allergy - Drug Targets (Discontinued) Total Carotenoids Content and Assessment of Carotene Profile by High- Performance Liquid Chromatography in Selected Vegetables of Bangladesh with Special Reference to Some Unconventional Varieties
Current Chromatography Pharmacotherapy of Sickle Cell Disease in Children
Current Pharmaceutical Design Development and Applications of Fluorescent Oligonucleotides
Current Organic Chemistry Adult Stem Cell Therapy for Cardiac Repair in Patients After Acute Myocardial Infarction Leading to Ischemic Heart Failure: An Overview of Evidence from the Recent Clinical Trials
Current Cardiology Reviews Proteomic Strategies for the Analysis of Carbonyl Groups on Proteins
Current Protein & Peptide Science Synthesis of Phosphorus, Arsenic and Antimony Ylides Containing the 1,3- Dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione Fragments
Letters in Organic Chemistry Applications of luminous bacteria enzymes in toxicology
Combinatorial Chemistry & High Throughput Screening