Abstract
Understanding the chemistry and biology of protein glycosylation is a major challenge in proteomics and glycomics research. Due to their pivotal role in the biosynthesis of complex oligosaccharides and glycoconjugates, protein glycosylation enzymes are targets of choice for the development of inhibitors. Glycosyltransferase and glypiation (GPI anchoring) inhibitors that are of potential therapeutic value for the treatment of diseases associated with glycosylation defects are reviewed in the light of recent developments.
Keywords: hydroxyproline, uronic acid, neuraminic acid, N-acetylgalactosamine, Congenital disorders of glycosylation, Glypiation
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
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