Abstract
Betulin, betulinic acid and their derived compounds are important pentacyclic lupane-type triterpenoids and exhibit diversified pharmacological activities like anti-HIV, antitumor, antimycotic, anti-inflammatory, antioxidant and immunomodulatory activities. Many new methods for the synthesis of potentially valuable betulin derived triterpenoids with potent bioactivity have been largely reported in the past few years. In this review, we will present the progress made on the synthesis of novel structural triterpenoids with excellent chemical or biological activity that have appeared from 2006 to 2012.
Keywords: Betulin, betulinic acid, heterocyclic derivatives, biological activity, synthetic method.
Mini-Reviews in Organic Chemistry
Title:Research and Development in Betulin and Betulinic Acid Derived Triterpenoids
Volume: 11 Issue: 3
Author(s): Wei Shi, Ning Tang and Weidong Yan
Affiliation:
Keywords: Betulin, betulinic acid, heterocyclic derivatives, biological activity, synthetic method.
Abstract: Betulin, betulinic acid and their derived compounds are important pentacyclic lupane-type triterpenoids and exhibit diversified pharmacological activities like anti-HIV, antitumor, antimycotic, anti-inflammatory, antioxidant and immunomodulatory activities. Many new methods for the synthesis of potentially valuable betulin derived triterpenoids with potent bioactivity have been largely reported in the past few years. In this review, we will present the progress made on the synthesis of novel structural triterpenoids with excellent chemical or biological activity that have appeared from 2006 to 2012.
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Cite this article as:
Shi Wei, Tang Ning and Yan Weidong, Research and Development in Betulin and Betulinic Acid Derived Triterpenoids, Mini-Reviews in Organic Chemistry 2014; 11 (3) . https://dx.doi.org/10.2174/1570193X1103140915112124
DOI https://dx.doi.org/10.2174/1570193X1103140915112124 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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