Abstract
Oleanolic acid (OA) is a natural pentacyclic triterpenoid acid with diverse biological activities including antiinflammation, suppression of tumor promotion, protection of the liver against toxic injury, and induction of differentiation. However, the potency of OA as an anti-cancer agent is relatively weak. Therefore, remarkable progress has been made in the modification of OA to improve its anti-cancer activity over the past few years. This paper reviews the progress mainly on anti-cancer activity of enone derivatives and nitric oxide (NO)-releasing derivatives of OA over the last decade.
Keywords: Anti-cancer, CDDO, enone derivative, nitric oxide (NO), NO-releasing derivative, oleanolic acid (OA).
Mini-Reviews in Organic Chemistry
Title:Recent Advances in Enone and NO-Releasing Derivatives of Oleanolic Acid with Anti-cancer Activity
Volume: 11 Issue: 3
Author(s): Qun-Feng Luo, Jin-Hong Liu and Li Chen
Affiliation:
Keywords: Anti-cancer, CDDO, enone derivative, nitric oxide (NO), NO-releasing derivative, oleanolic acid (OA).
Abstract: Oleanolic acid (OA) is a natural pentacyclic triterpenoid acid with diverse biological activities including antiinflammation, suppression of tumor promotion, protection of the liver against toxic injury, and induction of differentiation. However, the potency of OA as an anti-cancer agent is relatively weak. Therefore, remarkable progress has been made in the modification of OA to improve its anti-cancer activity over the past few years. This paper reviews the progress mainly on anti-cancer activity of enone derivatives and nitric oxide (NO)-releasing derivatives of OA over the last decade.
Export Options
About this article
Cite this article as:
Luo Qun-Feng, Liu Jin-Hong and Chen Li, Recent Advances in Enone and NO-Releasing Derivatives of Oleanolic Acid with Anti-cancer Activity, Mini-Reviews in Organic Chemistry 2014; 11 (3) . https://dx.doi.org/10.2174/1570193X1103140915112325
DOI https://dx.doi.org/10.2174/1570193X1103140915112325 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
![](/images/wayfinder.jpg)
- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Supplementation with Curcuma longa Reverses Neurotoxic and Behavioral Damage in Models of Alzheimer’s Disease: A Systematic Review
Current Neuropharmacology Recent Developments in the Chemical Biology of Epothilones
Current Pharmaceutical Design Trends in Mitochondrial Therapeutics for Neurological Disease
Current Medicinal Chemistry Structure, Function and Biological Relevance of Prolyl Oligopeptidase
Current Protein & Peptide Science Edelfosine in Membrane Environment - the Langmuir Monolayer Studies
Anti-Cancer Agents in Medicinal Chemistry Identification and Targeting of Tumor Escape Mechanisms: A New Hope for Cancer Therapy?
Current Pharmaceutical Design Polysulfated/Sulfonated Compounds for the Development of Drugs at the Crossroad of Viral Infection and Oncogenesis
Current Pharmaceutical Design Deubiquitinating Enzyme Inhibitors and their Potential in Cancer Therapy
Current Cancer Drug Targets Caspase-Independent Pathways of Programmed Cell Death: The Unraveling of New Targets of Cancer Therapy?
Current Cancer Drug Targets Neuroprotective Properties of Peroxisome Proliferator-Activated Receptor Alpha (PPARα) and its Lipid Ligands
Current Medicinal Chemistry Design and Development of Nanovehicle-Based Delivery Systems for Preventive or Therapeutic Supplementation with Flavonoids
Current Medicinal Chemistry Compounds From Celastraceae Targeting Cancer Pathways and Their Potential Application in Head and Neck Squamous Cell Carcinoma: A Review
Current Genomics Bacopa monnieri Prophylaxis Abrogates 3-nitropropionic Acid Induced Brain Mitochondrial Oxidative Stress Among Prepubertal Mice: In Vitro and In Vivo Evidences
Neuroscience and Biomedical Engineering (Discontinued) Targeting Striatal Metabotropic Glutamate Receptor Type 5 in Parkinson’s Disease: Bridging Molecular Studies and Clinical Trials
CNS & Neurological Disorders - Drug Targets Enhancing the Site-Specific Targeting of Macromolecular Anticancer Drug Delivery Systems
Current Drug Targets Agonists of the Tissue-Protective Erythropoietin Receptor in the Treatment of Parkinson’s Disease
Current Topics in Medicinal Chemistry Soothing the Inflamed Brain: Effect of Non-Steroidal Anti-Inflammatory Drugs on Alzheimers Disease Pathology
CNS & Neurological Disorders - Drug Targets Small Players With Big Roles: MicroRNAs as Targets to Inhibit Breast Cancer Progression
Current Drug Targets Targeting Drug-Resistant Prostate Cancer with Dual PI3K/mTOR Inhibition
Current Medicinal Chemistry Targeting Transcription Factor Binding to DNA by Competing with DNA Binders as an Approach for Controlling Gene Expression
Current Topics in Medicinal Chemistry