Recent Advances in Clarifying Prion Protein Functions Using Knockout Mice and Derived Cell Lines

Title: Recent Advances in Clarifying Prion Protein Functions Using Knockout Mice and Derived Cell Lines

Volume: 6 Issue: 5

Author(s): Akikazu Sakudo, Takashi Onodera, Yoshikazu Suganuma, Takanori Kobayashi, Keiichi Saeki and Kazuyoshi Ikuta

Affiliation:

Keywords: Prion protein, PrP-knockout mice, PrP-deficient cells, apoptosis, oxidative stress

Abstract: Considerable information on the functions of prion protein (PrP) has been accumulated. One experimental approach is the use of PrP gene-knockout mice and derived cell lines. This approach has contributed to elucidating the functions of cellular prion protein (PrPC), such as its anti-oxidative and anti-apoptotic roles. This review will introduce the recent advances in prion biology made possible by the availability of these tools.

Cite this article as:

Sakudo Akikazu, Onodera Takashi, Suganuma Yoshikazu, Kobayashi Takanori, Saeki Keiichi and Ikuta Kazuyoshi, Recent Advances in Clarifying Prion Protein Functions Using Knockout Mice and Derived Cell Lines, Mini-Reviews in Medicinal Chemistry 2006; 6 (5) . https://dx.doi.org/10.2174/138955706776876159