Abstract
Among the broad range of transition metal-catalyzed reactions, the Heck reaction is an attractive methodology frequently being used for the synthesis of natural and biologically active products, since a palladium-catalyzed reaction of this kind can directly create complex molecules under mild conditions from readily available starting materials. This feature article provides the comprehensive summary of currently available applications of this reaction in the total synthesis
Keywords: Cross-coupling, Heck reaction, Total synthesis, Natural product, Palladium.
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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