Recombinant Human Growth Hormone in Abstinent Androgenic-Anabolic Steroid Use: Psychological, Endocrine and Trophic Factor Effects

Title: Recombinant Human Growth Hormone in Abstinent Androgenic-Anabolic Steroid Use: Psychological, Endocrine and Trophic Factor Effects

Volume: 4 Issue: 1

Author(s): Michael R. Graham, Bruce Davies, Andrew Kicman, David Cowan, David Hullin and Julien S. Baker

Affiliation:

Keywords: Anxiety, body composition, cardiovascular, depression, psychology, insulin-like growth factor-I

Abstract: This study examined whether six days recombinant human growth hormone (rhGH) affected psychological profile in an abstinent androgenic-anabolic steroid (AAS) abusing group, compared with an abstinent AAS control group. Male subjects (n = 48) were assigned in a random fashion into one of two groups: (1): (n =24) control group (C); (2): (n =24) rhGH group (GH). A hospital anxiety scale (HADS) questionnaire was completed by all subjects. Physiological responses investigated included anthropometry. Biochemical markers examined included; serum glucose, sodium, urea, lipid profile, high sensitivity C-reactive protein (hsCRP), homocysteine (HCY), tetra-iodothyronine (T4), thyroid stimulating (TSH), luteinising (LH) and follicle stimulating (FSH) hormones, testosterone (T), prolactin (PRL), cortisol and insulin like growth factor-1 (IGF-I). HADS questionnaire significantly decreased in both anxiety (A) and depression (D) symptoms within GH (P < 0.017) and compared with C (P < 0.05). Body mass index (BMI) and fat-free mass index (FFMI) significantly increased (both P < 0.017) while body fat significantly decreased within GH (P < 0.017). IGF-I significantly increased within GH (P < 0.017) and significantly increased compared with C (P < 0.05). Serum sodium significantly increased (P < 0.017) and serum HCY, hsCRP, TSH and T4, significantly decreased within GH (all P < 0.017). PRL significantly increased and T4 significantly decreased compared with C (both P < 0.05). The findings of this study suggest that short term use of rhGH has beneficial effects on mental state in individuals who were previous abusers of AAS and appeared to have a beneficial effect on cardiovascular risk markers associated with adverse mental health.

Cite this article as:

Graham R. Michael, Davies Bruce, Kicman Andrew, Cowan David, Hullin David and Baker S. Julien, Recombinant Human Growth Hormone in Abstinent Androgenic-Anabolic Steroid Use: Psychological, Endocrine and Trophic Factor Effects, Current Neurovascular Research 2007; 4 (1) . https://dx.doi.org/10.2174/156720207779940699