Antiglucocorticoids, Neurogenesis and Depression

Title: Antiglucocorticoids, Neurogenesis and Depression

Volume: 9 Issue: 2

Author(s): Carlos P. Fitzsimons, Lenneke W.A. van Hooijdonk, John A. Morrow, Bernard W.M.M. Peeters, Niall Hamilton, Mark Craighead and Erno Vreugdenhil

Affiliation:

Keywords: Stress, glucocorticoid receptor, dentate gyrus, hippocampus, neurogenesis, antidepressants, depression, doublecortin- like kinase, anti-glucocorticoids

Abstract: Recent evidence suggests that antiglucocorticoids, like conventional antidepressants, may recover depressive symptoms by boosting hippocampal neurogenesis. Here, we explore several possible antiglucocorticoid-based antidepressive therapeutic strategies. Firstly, we review specific glucocorticoid receptor/antagonist interactions. Secondly, we discuss a potential new therapeutic target, doublecortin-like kinase, which regulates glucocorticoid signaling in neuronal progenitor cells.

Cite this article as:

Fitzsimons P. Carlos, van Hooijdonk W.A. Lenneke, Morrow A. John, Peeters W.M.M. Bernard, Hamilton Niall, Craighead Mark and Vreugdenhil Erno, Antiglucocorticoids, Neurogenesis and Depression, Mini-Reviews in Medicinal Chemistry 2009; 9 (2) . https://dx.doi.org/10.2174/138955709787316001