Stereoselective Synthesis and Antiproliferative Activity of Monoterpene-Fused 2- Imino-1,3-oxazines

Title:Stereoselective Synthesis and Antiproliferative Activity of Monoterpene-Fused 2- Imino-1,3-oxazines

Volume: 14 Issue: 4

Author(s): Zsolt Szakonyi*, Istvan Zupko and Ferenc Fulop

Affiliation:

• Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Szeged, H-6720 Szeged, Eotvos utca 6,Hungary

Keywords: Monoterpene, asymmetric synthesis, enantiopure chiral templates, 1, 3-amino alcohol, 1, 3-oxazine, antiproliferative.

Abstract: Background: In the recent years the 2-imino-1,3-thiazine and 2-iminothiazolidine ring systems can be found as moieties in biologically relevant compounds, including BACE1 inhibitors, or cannabinoid receptor agonists, while monoterpene-based 2-imino-1,3-thiazines, prepared from chiral 1,3-amino alcohols exhibiting pronounced antiproliferative activity.

Methods: The antiproliferative activities of the prepared compounds were determined in vitro against a panel of human adherent cancer cell lines including HeLa, MCF7 and A431 by MTT assay.

Results: Starting from pinane-, apopinane- and carane-based β-amino acid derivatives, 1,3-amino alcohols were prepared via two-step syntheses. The reactions of the product 1,3-amino alcohols and aryl isothiocyanates yielded ϒ-hydroxythioureas, which were transformed to monoterpene-fused 2-imino-1,3-oxazines via base-catalysed ring closure. The antiproliferative activities of these 2-imino-1,3-oxazines were examined and the structure–activity relationships were studied from the aspects of the type and stereochemistry of the monoterpene ring and the substituent effects on the 1,3-oxazine ring system. The N-unsubstituted monoterpene-based derivatives exhibited considerable antiproliferative activity against a panel of human adherent cancer cell lines (HeLa, MCF7 and A431).

Conclusions: A mild and efficient method has been developed for the synthesis of 2-imino-1,3-oxazines by the ring closure of thiourea adducts of 1,3-amino alcohols. The resulting 1,3-oxazines exert marked antiproliferative action on a panel of human cancer cell lines.

Cite this article as:

Szakonyi Zsolt*, Zupko Istvan and Fulop Ferenc, Stereoselective Synthesis and Antiproliferative Activity of Monoterpene-Fused 2- Imino-1,3-oxazines, Current Organic Synthesis 2017; 14 (4) . https://dx.doi.org/10.2174/1570179414666161116110813

DOI https://dx.doi.org/10.2174/1570179414666161116110813	Print ISSN 1570-1794
Publisher Name Bentham Science Publisher	Online ISSN 1875-6271