Recent Progress on Fucosyltransferase Inhibitors

Title:Recent Progress on Fucosyltransferase Inhibitors

Volume: 12 Issue: 14

Author(s): Pedro Merino, Tomas Tejero, Ignacio Delso, Ramon Hurtado-Guerrero, Asier Gomez-SanJuan and David Sadaba

Affiliation:

Keywords: Fucosyltransferases, Carbohydrate mimics, Glycoconjugates, Piperidines, Pyrrolidines, C-Glycosides, structure-activity-relationship, polyhydroxylated

Abstract: Fucosyltransferases (FucTs) are enzymes that transfer L-fucose from GDP-fucose to a glycoside or a peptide. They have important roles in a variety of diseases including cancer and autoimmune disorders, viral and bacterial infections and inflammatory processes, and thus they represent important drug targets for the development of agents for the treatment of such disorders. This review highlights recent developments regarding carbohydrate mimics as inhibitors of FucTs. The most recent and relevant synthetic strategies are described.

Cite this article as:

Merino Pedro, Tejero Tomas, Delso Ignacio, Hurtado-Guerrero Ramon, Gomez-SanJuan Asier and Sadaba David, Recent Progress on Fucosyltransferase Inhibitors, Mini-Reviews in Medicinal Chemistry 2012; 12 (14) . https://dx.doi.org/10.2174/138955712803832753