Role of TGF- β in the Tumor Stroma

Title: Role of TGF- β in the Tumor Stroma

Volume: 8 Issue: 6

Author(s): H. P.H. Naber, P. ten Dijke and E. Pardali

Affiliation:

Keywords: TGF-β, tumor stroma, CAF, angiogenesis, immune cells

Abstract: Recent findings have demonstrated that the tumor stroma actively contributes to tumorigenesis. The communication of malignant cells and tumor stromal components is orchestrated in part by a network of growth factors. One of these growth factors is transforming growth factor-β (TGF-β), a secreted multifunctional protein that acts in a highly cellular contextual manner. TGF-β can either stimulate or inhibit the tumor-promoting effects of the different components of the tumor stroma. In this review, we discuss our current understanding on how TGF-β influences different stromal compartments.

Cite this article as:

Naber P.H. H., ten Dijke P. and Pardali E., Role of TGF- β in the Tumor Stroma, Current Cancer Drug Targets 2008; 8 (6) . https://dx.doi.org/10.2174/156800908785699342