Recent Opportunities and Challenges in Selective C-H Functionalization of Methyl Azaarenes: A Highlight from 2010 to 2020 Studies

Title:Recent Opportunities and Challenges in Selective C-H Functionalization of Methyl Azaarenes: A Highlight from 2010 to 2020 Studies

Volume: 18 Issue: 8

Author(s): Fahimeh Abedinifar, Mohammad Mahdavi*, Mehdi Asadi , Haleh Hamedifar , Samira Ansari*Bagher Larijani

Affiliation:

• Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran 14176,Iran

• CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj,Iran

Keywords: Azaarenes, pharmaceutical, C-H functionalization, alkenylation, oxidative, cyclization.

Abstract: Azaarenes are unique scaffolds that are frequently found in pharmaceuticals. Herein we have summarized the recent synthetic available methods in C–H functionalization of methylazaarenes from 2010 to 2020. Multiple approaches involving halogenation, alkylation via different methods, alkenylation, oxidative functionalization, and cyclization of the methylazaarenes will be discussed in this review.

Cite this article as:

Abedinifar Fahimeh , Mahdavi Mohammad *, Asadi Mehdi, Hamedifar Haleh , Ansari Samira *, Larijani Bagher , Recent Opportunities and Challenges in Selective C-H Functionalization of Methyl Azaarenes: A Highlight from 2010 to 2020 Studies, Current Organic Synthesis 2021; 18 (8) . https://dx.doi.org/10.2174/1566524021666210614141628