摘要
抗菌素耐药性 (AMR) 是当今医学面临的主要挑战之一，因为它已成为影响多重感染治疗并影响公共健康的全球性问题。这种抗性是由于细菌产生选择性的压力促进机制来逃避常规药物的作用，这也与不良反应有关。这些多重耐药菌引起的感染可能会降低有效治疗的可能性；这种情况增加了发病率和死亡率以及治疗费用。因此，为了将联合治疗确立为控制多重耐药菌引起的感染的策略，2015 年至 2020 年间在 PubMed、Scopus 和 Science Direct 等数据库中进行了文献检索。对文章的详尽审查允许对信息进行批判性分析。确定了获得具有抗微生物潜力的药物的机制，它们的生物活性以及它们组合对多重耐药细菌的可能影响，作为传染病控制的替代方法和减少抗生素使用的反应。联合疗法作为一种创新的治疗替代方案被提出，它使用可以通过三种途径获得的非抗生素物质：药物、合成物质和天然产物的重新定位。通过这种方式，提供了重要的元素来指导旨在减少抗菌素耐药性的研究。
关键词: 抗菌素耐药性、传染病、药物组合、天然产物、联合疗法、协同作用
图形摘要
[1]
Karine de Sousa A, Rocha JE, Gonçalves de Souza T, Sampaio de Freitas T, Ribeiro-Filho J, Melo Coutinho HD. New roles of fluoxetine in pharmacology: Antibacterial effect and modulation of antibiotic activity. Microb Pathog 2018; 123: 368-71.
[http://dx.doi.org/10.1016/j.micpath.2018.07.040] [PMID: 30056107]
[http://dx.doi.org/10.1016/j.micpath.2018.07.040] [PMID: 30056107]
[2]
Nørgaard SM, Jensen CS, Aalestrup J, Vandenbroucke-Grauls CMJE, de Boer MGJ, Pedersen AB. Choice of therapeutic interventions and outcomes for the treatment of infections caused by multidrug-resistant gram-negative pathogens: a systematic review. Antimicrob Resist Infect Control 2019; 8: 170.
[http://dx.doi.org/10.1186/s13756-019-0624-1] [PMID: 31709047]
[http://dx.doi.org/10.1186/s13756-019-0624-1] [PMID: 31709047]
[3]
Mikhail S, Singh NB, Kebriaei R, et al. Evaluation of the synergy of ceftazidime-avibactam in combination with meropenem, amikacin, aztreonam, colistin, or fosfomycin against well-characterized multidrug-resistant klebsiella pneumoniae and pseudomonas aeruginosa. Antimicrob Agents Chemother 2019; 63(8): e00779-819.
[http://dx.doi.org/10.1128/AAC.00779-19] [PMID: 31182535]
[http://dx.doi.org/10.1128/AAC.00779-19] [PMID: 31182535]
[4]
Djeussi DE, Noumedem JAK, Ngadjui BT, Kuete V. Antibacterial and antibiotic-modulation activity of six Cameroonian medicinal plants against Gram-negative multi-drug resistant phenotypes. BMC Complement Altern Med 2016; 16: 124.
[http://dx.doi.org/10.1186/s12906-016-1105-1] [PMID: 27142515]
[http://dx.doi.org/10.1186/s12906-016-1105-1] [PMID: 27142515]
[5]
Ibrahim YM, Abouwarda AM, Nasr T, Omar FA, Bondock S. Antibacterial and anti-quorum sensing activities of a substituted thiazole derivative against methicillin-resistant Staphylococcus aureus and other multidrug-resistant bacteria. Microb Pathog 2020; 149: 104500.
[http://dx.doi.org/10.1016/j.micpath.2020.104500] [PMID: 32926996]
[http://dx.doi.org/10.1016/j.micpath.2020.104500] [PMID: 32926996]
[6]
Bezerra CF, Camilo CJ, do Nascimento Silva MK, de Freitas TS, Ribeiro-Filho J, Coutinho HDM. Vanillin selectively modulates the action of antibiotics against resistant bacteria. Microb Pathog 2017; 113: 265-8.
[http://dx.doi.org/10.1016/j.micpath.2017.10.052] [PMID: 29107747]
[http://dx.doi.org/10.1016/j.micpath.2017.10.052] [PMID: 29107747]
[7]
Schmid A, Wolfensberger A, Nemeth J, Schreiber PW, Sax H, Kuster SP. Monotherapy versus combination therapy for multidrug-resistant Gram-negative infections: Systematic Review and Meta-Analysis. Sci Rep 2019; 9(1): 15290.
[http://dx.doi.org/10.1038/s41598-019-51711-x]
[http://dx.doi.org/10.1038/s41598-019-51711-x]
[8]
Valcourt C, Saulnier P, Umerska A, et al. Synergistic interactions between doxycycline and terpenic components of essential oils encapsulated within lipid nanocapsules against gram negative bacteria. Int J Pharm 2016; 498(1-2): 23-31.
[http://dx.doi.org/10.1016/j.ijpharm.2015.11.042] [PMID: 26631640]
[http://dx.doi.org/10.1016/j.ijpharm.2015.11.042] [PMID: 26631640]
[9]
Oliveira MTA, Teixeira AMR, Cassiano CJM, et al. Modulation of the antibiotic activity against multidrug resistant strains of 4-(phenylsulfonyl) morpholine. Saudi J Biol Sci 2016; 23(1): 34-8.
[http://dx.doi.org/10.1016/j.sjbs.2015.02.001] [PMID: 26858536]
[http://dx.doi.org/10.1016/j.sjbs.2015.02.001] [PMID: 26858536]
[10]
Luiz De Sousa Júnior D, Patrícia P, Cordeiro M, De Sousa Silveira Z, Macêdo NS, Boligon AA. Phytochemical profile of leaves extract of Azadirachta indica A. Juss and toxicity against Drosophila melanogaster 2018; Vol. 2 Available from:
http://sciforum.net/conference/mol2net-02/wrsamc
[11]
Rao T, Tan Z, Peng J, et al. The pharmacogenetics of natural products: A pharmacokinetic and pharmacodynamic perspective. Pharmacol Res 2019; 146: 104283.
[http://dx.doi.org/10.1016/j.phrs.2019.104283] [PMID: 31129178]
[http://dx.doi.org/10.1016/j.phrs.2019.104283] [PMID: 31129178]
[12]
Thomford NE, Senthebane DA, Rowe A, et al. Natural products for drug discovery in the 21st century: Innovations for novel drug discovery. Int J Mol Sci 2018; 19(6): 1578.
[http://dx.doi.org/10.3390/ijms19061578] [PMID: 29799486]
[http://dx.doi.org/10.3390/ijms19061578] [PMID: 29799486]
[13]
Vandevelde NM, Tulkens PM, Van Bambeke F. Modulating antibiotic activity towards respiratory bacterial pathogens by co-medications: a multi-target approach. Drug Discov Today 2016; 21(7): 1114-29.
[http://dx.doi.org/10.1016/j.drudis.2016.04.001] [PMID: 27094105]
[http://dx.doi.org/10.1016/j.drudis.2016.04.001] [PMID: 27094105]
[14]
Gómez-Junyent J, Benavent E, Sierra Y, et al. Efficacy of ceftolozane/tazobactam, alone and in combination with colistin, against multidrug-resistant Pseudomonas aeruginosa in an in vitro biofilm pharmacodynamic model. Int J Antimicrob Agents 2019; 53(5): 612-9.
[http://dx.doi.org/10.1016/j.ijantimicag.2019.01.010] [PMID: 30682497]
[http://dx.doi.org/10.1016/j.ijantimicag.2019.01.010] [PMID: 30682497]
[15]
Horcajada JP, Montero M, Oliver A, et al. Epidemiology and treatment of multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosa infections. Clin Microbiol Rev 2019; 32(4): e00031-19.
[http://dx.doi.org/10.1128/CMR.00031-19] [PMID: 31462403]
[http://dx.doi.org/10.1128/CMR.00031-19] [PMID: 31462403]
[16]
Morais-Braga MFB, Sales DL, dos Santos Silva F, Chaves TP, de Carvalho Nilo Bitu V, Avilez WMT. Psidium guajava L. and Psidium brownianum Mart ex DC. potentiate the effect of antibiotics against Gram-positive and Gram-negative bacteria. Eur J Integr Med 2016; 8(5): 683-7.
[http://dx.doi.org/10.1016/j.eujim.2016.07.001]
[http://dx.doi.org/10.1016/j.eujim.2016.07.001]
[17]
Gelmini F, Belotti L, Vecchi S, Testa C, Beretta G. Air dispersed essential oils combined with standard sanitization procedures for environmental microbiota control in nosocomial hospitalization rooms. Complement Ther Med 2016; 25: 113-9.
[http://dx.doi.org/10.1016/j.ctim.2016.02.004] [PMID: 27062958]
[http://dx.doi.org/10.1016/j.ctim.2016.02.004] [PMID: 27062958]
Article Metrics
32
1