Abstract
Aromatase is a target of pharmacological interest for the treatment of estrogen-dependent cancers. In an effort to develop new therapies to treat breast cancer, a series of 1-phenethyl-1H-[1,2,4]triazole derivatives (6a-6h) were synthesized and evaluated for their efficacy as aromatase inhibitors. Biological tests suggest that these compounds exhibit mild to moderate inhibitory activity to aromatase.
Keywords: Estrogen, Aromatase inhibitor, Anticancer, Nonsteroidal, Synthesis, 1H-[1,2,4]triazole
Letters in Drug Design & Discovery
Title: Synthesis and Biological Evaluation of Aromatase Inhibitors
Volume: 6 Issue: 3
Author(s): Jinpei Zhou, Huibin Zhang, Hai Qian, Liang Lin, Wenlong Huang and Shuaijian Ni
Affiliation:
Keywords: Estrogen, Aromatase inhibitor, Anticancer, Nonsteroidal, Synthesis, 1H-[1,2,4]triazole
Abstract: Aromatase is a target of pharmacological interest for the treatment of estrogen-dependent cancers. In an effort to develop new therapies to treat breast cancer, a series of 1-phenethyl-1H-[1,2,4]triazole derivatives (6a-6h) were synthesized and evaluated for their efficacy as aromatase inhibitors. Biological tests suggest that these compounds exhibit mild to moderate inhibitory activity to aromatase.
Export Options
About this article
Cite this article as:
Zhou Jinpei, Zhang Huibin, Qian Hai, Lin Liang, Huang Wenlong and Ni Shuaijian, Synthesis and Biological Evaluation of Aromatase Inhibitors, Letters in Drug Design & Discovery 2009; 6 (3) . https://dx.doi.org/10.2174/157018009787847846
DOI https://dx.doi.org/10.2174/157018009787847846 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
Related Journals
Related Books
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Non-Coding RNA in Brain Development and Disorder
Current Medicinal Chemistry Gene Expression Assay in the Management of Early Breast Cancer
Current Medicinal Chemistry Targeting Urokinase and the Transferrin Receptor with Novel, Anti-Mitotic N-Alkylisatin Cytotoxin Conjugates Causes Selective Cancer Cell Death and Reduces Tumor Growth
Current Cancer Drug Targets Genetics and Epigenetics of Lung Cancer: Mechanisms and Future Perspectives
Current Cancer Therapy Reviews Signal Transduction Targets in Prostate Cancer
Current Signal Transduction Therapy HPV Pathway Profiling: HPV Related Cervical Dysplasia and Carcinoma Studies
Current Pharmaceutical Design The Current WHO Classification of Tumours of the Central Nervous System: Histopathology and Additional Diagnostic Methods
Current Medical Imaging A Review on Mechanisms of Anti Tumor Activity of Chalcones
Anti-Cancer Agents in Medicinal Chemistry Phosphocitrate, A Potential Therapeutic Agent for Calcium Crystal Deposition Diseases
Current Rheumatology Reviews Neurokinin-1 Receptor Antagonist Can Prevent the Delayed Phase in Patients: A Single Center Retrospect Study
Anti-Cancer Agents in Medicinal Chemistry The PI3K/AKT/mTOR-Signal Transduction Pathway as Drug Target in Triple-Negative Breast Cancer
Clinical Cancer Drugs Competitive Interaction Between Plasma Omega-3 Fatty Acids and Arachidonic Acid is Related to Down-Regulation of A Signaling Mediator
Medicinal Chemistry Concepts for Nano-delivery of Therapeutic Immunomodulatory Agents
Current Bionanotechnology (Discontinued) The Intestinal Environment in Health and Disease – Recent Insights on the Potential of Intestinal Bacteria to Influence Human Health
Current Pharmaceutical Design Asafoetida, Natural Medicine for Future
Current Nutrition & Food Science Meet Our Editorial Board Member
Letters in Drug Design & Discovery Antiangiogenesis in Myelodysplastic Syndrome
Current Cancer Drug Targets Altered Glycosylation of Proteins in Cancer: What Is the Potential for New Anti-Tumour Strategies
Anti-Cancer Agents in Medicinal Chemistry The Application of lncRNAs in Cancer Treatment and Diagnosis
Recent Patents on Anti-Cancer Drug Discovery Anti-miRNA-23a Oligonucleotide Suppresses Glioma Cells Growth by Targeting Apoptotic Protease Activating Factor-1
Current Pharmaceutical Design