The Dopaminergic Dysfunction and Altered Working Memory Performance of Aging Mice Lacking Gamma-synuclein Gene

Title:The Dopaminergic Dysfunction and Altered Working Memory Performance of Aging Mice Lacking Gamma-synuclein Gene

Volume: 17 Issue: 8

Author(s): Viktor S. Kokhan, Tat`yana G. Kokhan, Anna N. Samsonova, Vladimir P. Fisenko, Aleksey A. Ustyugov and Gjumrakch Aliev*

Affiliation:

• Institute of Physiologically Active Compounds RAS, Chernogolovka,Russian Federation

Keywords: Gamma-synuclein, working memory, passive-avoidance test, and amphetamine induced locomotion, soluble proteins, neural tissue.

Abstract: Background: It was previously shown that inactivation of gamma-synuclein which is a small soluble neuronal protein affects psycho-emotional status and cognitive abilities in knock-out mice.

Objective: Determine the role of gamma-synuclein inactivation on memory performance in aging animals.

Method: We used the passive avoidance test and acute amphetamine administration in aging gammasynuclein knock-out mice.

Results: As a result, we found moderate aging-unlinked deficit of dopaminergic neurotransmitter system of gamma-synuclein knock-out mice. At the same time, the evidence of progressive synaptic vesicle trafficking machinery impairment was obtained.

Conclusion: Therefore most likely these dysfunctions are associated with a reduction in the highefficient learning performance in tests that require intact working memory.

Cite this article as:

Kokhan S. Viktor , Kokhan G. Tat`yana, Samsonova N. Anna , Fisenko P. Vladimir , Ustyugov A. Aleksey and Aliev Gjumrakch *, The Dopaminergic Dysfunction and Altered Working Memory Performance of Aging Mice Lacking Gamma-synuclein Gene, CNS & Neurological Disorders - Drug Targets 2018; 17 (8) . https://dx.doi.org/10.2174/1871527317666180726095734