The Role of Targeted HIV Screening in the Emergency Department: A Scoping Review

Ornella       Spagnolello; Bernadette       Gallagher; Nazir       Lone; Giancarlo       Ceccarelli; Gabriella       D’Ettorre; Matthew    J.   Reed

doi:10.2174/1570162X18666201123113905

Abstract

Background: Human immunodeficiency virus (HIV) infection continues to expand worldwide, and a significant proportion of infection is still undiagnosed. Recent studies have addressed the impact and feasibility of ‘opt-out’ HIV screening in Emergency Departments (EDs) in urban settings at high HIV prevalence, whereas little is known about the yield of implementing ‘targeted’ HIV testing, especially in low-prevalence areas.

Objective: The present study undertakes a scoping review of research carried out on the implementation of targeted HIV screening of adult in EDs to determine the impact, feasibility and acceptability of HIV testing in different HIV prevalence settings.

Design: Online databases (EMBASE, MEDLINE) were used to identify papers published between 2000 to 2020. A three-concept search was employed with HIV (HIV, Human immunodeficiency virus infection, HIV infections), targeted testing (Target, screening or testing) and emergency medicine (Emergency Service, emergency ward, A&E, accident and emergency or Emergency Department) (28^th February 2020). Only full-text articles written in English, French, Spanish or Italian and using impact and/or feasibility and/or acceptability of the program as primary or secondary outcomes were analysed.

Results: The search provided 416 articles. Of these, 12 met inclusion criteria and were included in the final review. Most of the included studies were carried out in the United States (n=8; 67%) and in areas of high HIV prevalence (n=11; 92%). Three (20%) were randomized control studies. While the rate of newly diagnosed HIV cases varied widely (0.03-2.2%), likely due to methodological heterogeneity between studies, the linkage of new HIV diagnosis was often high (80-100%) and median CD4+ cell count was always greater than 200 cells per microliter. Targeted HIV screening was found to be cost-effective (out of 2 studies) and well accepted by participants (out 2 studies).

Conclusions: Targeted HIV screening at the ED can be impactful, feasible and well accepted, but often requires extra funding and staff. Most previous work has focused on areas of high disease prevalence.

Keywords: HIV, Targeted screening, emergency department, public health, early diagnosis, low-prevalence areas.

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UNAIDS data 2018 Joint United Nations Programme on HIV/AIDS (UNAIDS) UNAIDS data 2018 European Centre for Disease Prevention and Control. Thematic report:continuum of HIV care Monitoring implementation of the Dublin Declaration on Partnership to Fight HIV/AIDS in Europe and Central Asia: 2017 progress report. Stockholm: ECDC 2017. UNAIDS AN AMBITIOUS TREATMENT TARGET TO HELP END THE AIDS EPIDEMIC UNAIDS 90-90-90: Curr Opin HIV AIDS Rodger A.J. 11 487 2016 10.1097/COH.0000000000000307 Rodger A.J.; Sabin C.A.; How have guidelines on when to start antiretroviral therapy affected survival of people living with HIV infection? Curr Opin HIV AIDS 2016,11(5),487-491 Curr HIV Res Sobrino-Vegas P. 7 224 2009 10.2174/157016209787581535 Sobrino-Vegas P.; García-San Miguel L.; Caro-Murillo A.M.; Miró J.M.; Viciana P.; Tural C.; Saumoy M.; Santos I.; Sola J.; del Amo J.; Moreno S.; Delayed diagnosis of HIV infection in a multicenter cohort: prevalence, risk factors, response to HAART and impact on mortality. Curr HIV Res CoRIS2009,7(2),224-230 Gac Sanit Teira Cobo R 21 66 2007 Teira Cobo R; Suárez Lozano I; Santamaría Jáuregui JM; Terrón Pernía A; Domingo Pedrol P; González García J; Cosín Ochaita J; Ribera Pascuet E; Sánchez T; Roca Villanueva B; Viciana Fernández P; García Alcalde ML; Geijo Martínez P; Galindo Puerto P; Vergara Campos A; Lozano de León Naranjo F; Muñoz Sánchez A; Tebas P; Diagnóstico tardío de la infección por el virus de la inmunodeficiencia humana en la Cohorte VACH (1997-2002) Delayed diagnosis of HIV infection in the Spanish VACH cohort [1997-2002] Gac Sanit 2007,21(1),66-9 N Engl J Med Kitahata M.M. 360 1815 2009 10.1056/NEJMoa0807252 Kitahata M.M.; Gange S.J.; Abraham A.G.; Merriman B.; Saag M.S.; Justice A.C.; Hogg R.S.; Deeks S.G.; Eron J.J.; Brooks J.T.; Rourke S.B.; Gill M.J.; Bosch R.J.; Martin J.N.; Klein M.B.; Jacobson L.P.; Rodriguez B.; Sterling T.R.; Kirk G.D.; Napravnik S.; Rachlis A.R.; Calzavara L.M.; Horberg M.A.; Silverberg M.J.; Gebo K.A.; Goedert J.J.; Benson C.A.; Collier A.C.; Van Rompaey S.E.; Crane H.M.; McKaig R.G.; Lau B.; Freeman A.M.; Moore R.D.; Effect of early versus deferred antiretroviral therapy for HIV on survival. N Engl J Med NA-ACCORD Investigators2009,360(18),1815-1826 Clin Infect Dis May M.T. 62 1571 2016 10.1093/cid/ciw183 May M.T.; Vehreschild J.J.; Trickey A.; Obel N.; Reiss P.; Bonnet F.; Mary-Krause M.; Samji H.; Cavassini M.; Gill M.J.; Shepherd L.C.; Crane H.M.; d’Arminio Monforte A.; Burkholder G.A.; Johnson M.M.; Sobrino-Vegas P.; Domingo P.; Zangerle R.; Justice A.C.; Sterling T.R.; Miró J.M.; Sterne J.A.C.; Boulle A.; Stephan C.; Miro J.M.; Cavassini M.; Chêne G.; Costagliola D.; Dabis F.; Monforte A.D.; Del Amo J.; Van Sighem A.; Fätkenheuer G.; Gill J.; Guest J.; Haerry D.H.; Hogg R.; Justice A.; Shepherd L.; Obel N.; Crane H.; Smith C.; Reiss P.; Saag M.; Sterling T.; Teira R.; Williams M.; Zangerle R.; Sterne J.; May M.; Ingle S.; Trickey A.; Mortality according to CD4 count at start of combination antiretroviral therapy among HIV-infected patients fol- lowed for up to 15 years after start of treatment: collaborative cohort study. Clin Infect Dis Antiretroviral Therapy Cohort Collaboration (ART-CC)2016,62(12),1571-1577 Lancet Infect Dis Grinsztejn B. 14 281 2014 10.1016/S1473-3099(13)70692-3 Grinsztejn B.; Hosseinipour M.C.; Ribaudo H.J.; Swindells S.; Eron J.; Chen Y.Q.; Wang L.; Ou S.S.; Anderson M.; McCauley M.; Gamble T.; Kumarasamy N.; Hakim J.G.; Kumwenda J.; Pilotto J.H.; Godbole S.V.; Chariyalertsak S.; de Melo M.G.; Mayer K.H.; Eshleman S.H.; Piwowar-Manning E.; Makhema J.; Mills L.A.; Panchia R.; Sanne I.; Gallant J.; Hoffman I.; Taha T.E.; Nielsen-Saines K.; Celentano D.; Essex M.; Havlir D.; Cohen M.S.; Effects of early versus delayed initiation of antiretroviral treatment on clinical outcomes of HIV-1 infection: results from the phase 3 HPTN 052 randomised controlled trial. Lancet Infect Dis HPTN 052-ACTG Study Team2014,14(4),281-290 N Engl J Med Danel C. 373 808 2015 Danel C.; Moh R.; Trial of early antiretrovirals and isoniazid preventive therapy in Africa N Engl J Med TEMPRANO ANRS 12136 Study Group2015,373,808-822 N Engl J Med Lundgren J.D. 373 795 2015 10.1056/NEJMoa1506816 Lundgren J.D.; Babiker A.G.; Gordin F.; Emery S.; Grund B.; Sharma S.; Avihingsanon A.; Cooper D.A.; Fätkenheuer G.; Llibre J.M.; Molina J.M.; Munderi P.; Schechter M.; Wood R.; Klingman K.L.; Collins S.; Lane H.C.; Phillips A.N.; Neaton J.D.; Initiation of antiretroviral therapy in early asymptomatic HIV infection. N Engl J Med INSIGHT START Study Group2015,373(9),795-807 Lancet Infect Dis Miller W.C. 13 459 2013 10.1016/S1473-3099(12)70314-6 Miller W.C.; Powers K.A.; Smith M.K.; Cohen M.S.; Community viral load as a measure for assessment of HIV treatment as prevention. Lancet Infect Dis 2013,13(5),459-464 N Engl J Med Cohen M.S. 375 830 2016 10.1056/NEJMoa1600693 Cohen M.S.; Chen Y.Q.; McCauley M.; Gamble T.; Hosseinipour M.C.; Kumarasamy N.; Hakim J.G.; Kumwenda J.; Grinsztejn B.; Pilotto J.H.; Godbole S.V.; Chariyalertsak S.; Santos B.R.; Mayer K.H.; Hoffman I.F.; Eshleman S.H.; Piwowar-Manning E.; Cottle L.; Zhang X.C.; Makhema J.; Mills L.A.; Panchia R.; Faesen S.; Eron J.; Gallant J.; Havlir D.; Swindells S.; Elharrar V.; Burns D.; Taha T.E.; Nielsen-Saines K.; Celentano D.D.; Essex M.; Hudelson S.E.; Redd A.D.; Fleming T.R.; antiretroviral therapy for the prevention of hiv-1 transmission. N Engl J Med HPTN 052 study team2016,375(9),830-839 N Engl J Med Cohen M.S. 365 493 2011 10.1056/NEJMoa1105243 Cohen M.S.; Chen Y.Q.; McCauley M.; Gamble T.; Hosseinipour M.C.; Kumarasamy N.; Hakim J.G.; Kumwenda J.; Grinsztejn B.; Pilotto J.H.; Godbole S.V.; Mehendale S.; Chariyalertsak S.; Santos B.R.; Mayer K.H.; Hoffman I.F.; Eshleman S.H.; Piwowar-Manning E.; Wang L.; Makhema J.; Mills L.A.; de Bruyn G.; Sanne I.; Eron J.; Gallant J.; Havlir D.; Swindells S.; Ribaudo H.; Elharrar V.; Burns D.; Taha T.E.; Nielsen-Saines K.; Celentano D.; Essex M.; Fleming T.R.; Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med HPTN 052 Study Team2011,365(6),493-505 HIV Med Krentz H.B. 5 93 2004 10.1111/j.1468-1293.2004.00193.x Krentz H.B.; Auld M.C.; Gill M.J.; The high cost of medical care for patients who present late (CD4 <200 cells/microL) with HIV infection. HIV Med 2004,5(2),93-98 Martı’nez Colubi M, Pe’rez Elı’as MJ, Muriel A. Delayed diagnosis of HIV Infection: Prevalence, risk factors and high costs 13th European AIDS Conference/EACS. Belgrade, Serbia. 2011; pp. 12-5. Eur J Health Econ Guillon M. 19 327 2018 10.1007/s10198-017-0886-6 Guillon M.; Celse M.; Geoffard P.Y.; Economic and public health consequences of delayed access to medical care for migrants living with HIV in France. Eur J Health Econ 2018,19(3),327-340 Pharmacoeconomics Nosyk B. 33 243 2015 10.1007/s40273-014-0229-8 Nosyk B.; Lima V.; Colley G.; Yip B.; Hogg R.S.; Montaner J.S.; Costs of health resource utilization among HIV-positive individuals in British Columbia, Canada: results from a population-level study. Pharmacoeconomics 2015,33(3),243-253 Med Care Fleishman J.A. 48 1071 2010 10.1097/MLR.0b013e3181f81c4a Fleishman J.A.; Yehia B.R.; Moore R.D.; Gebo K.A.; The economic burden of late entry into medical care for patients with HIV infection. Med Care HIV Research Network2010,48(12),1071-1079 Pharmacoeconomics Levy A. 28 35 2010 10.2165/11587430-000000000-00000 Levy A.; Johnston K.; Annemans L.; Tramarin A.; Montaner J.; The impact of disease stage on direct medical costs of HIV management: a review of the international literature. Pharmacoeconomics 2010,28(Suppl. 1),35-47 Lancet David R.McGowan 15 2012 10.1016/S0140-6736(12)61537-2 David R.McGowan; David R.McGowan; Norris Joseph M; Smith Matthew D; Lad Meher; Routine testing for HIV in patients undergoing elective surgery. Lancet 2012,15 AIDS Care Chapman K. 7 125 1995 10.1080/09540129550126632 Chapman K.; Meadows J.; Catalan J.; Gazzard B.; Testing patients for HIV before surgery: the views of doctors performing surgery. AIDS Care 1995,7(2),125-128 Arch Surg Fournier A.M. 124 1038 1989 10.1001/archsurg.1989.01410090044009 Fournier A.M.; Zeppa R.; Preoperative screening for HIV infection. A balanced view for the practicing surgeon. Arch Surg 1989,124(9),1038-1040 International Journal of Contemporary Medical Research Mohan Manjul 2454 Mohan Manjul; Preoperative Screening of HIV, HBV, HCV Essential for Surgical Team and Patients both - A Research Study in Department of Surgery, Tertiary Care Institute of North India, International Journal of Contemporary Medical Research ,2454-7379 The Journal of Bone and Joint Surgery Harrison W. J. 87-B Harrison W. J.; HIV/AIDS in trauma and orthopaedic surgery The Journal of Bone and Joint Surgery ,87-B(9) J Obstet Gynaecol Can Keenan-Lindsay L. 28 1103 2006 10.1016/S1701-2163(16)32327-1 Keenan-Lindsay L.; Yudin M.H.; HIV screening in pregnancy. J Obstet Gynaecol Can INFECTIOUS DISEASES COMMITTEE2006,28(12),1103-1107 BMJ Postma M.J. 318 1656 1999 10.1136/bmj.318.7199.1656 Postma M.J.; Beck E.J.; Mandalia S.; Sherr L.; Walters M.D.; Houweling H.; Jager J.C.; Universal HIV screening of pregnant women in England: cost effectiveness analysis. BMJ 1999,318(7199),1656-1660 BMC Infect Dis Op de Coul E.L. 11 185 2011 10.1186/1471-2334-11-185 Op de Coul E.L.; Hahné S.; van Weert Y.W.; Oomen P.; Smit C.; van der Ploeg K.P.; Notermans D.W.; Boer K.; van der Sande M.A.; Antenatal screening for HIV, hepatitis B and syphilis in the Netherlands is effective. BMC Infect Dis 2011,11,185 Am J Obstet Gynecol Ecker J.L. 174 716 1996 10.1016/S0002-9378(96)70455-6 Ecker J.L.; The cost-effectiveness of human immunodeficiency virus screening in pregnancy. Am J Obstet Gynecol 1996,174(2),716-721 Sex Transm Infect Bristow C.C. 92 340 2016 10.1136/sextrans-2015-052367 Bristow C.C.; Larson E.; Anderson L.J.; Klausner J.D.; Cost-effectiveness of HIV and syphilis antenatal screening: a modelling study. Sex Transm Infect 2016,92(5),340-346 Euro Surveill Giraudon I. 14 8 2009 Giraudon I.; Forde J.; Maguire H.; Arnold J.; Permalloo N.; Antenatal screening and prevalence of infection: surveillance in London, 2000-2007. Euro Surveill 2009,14(9),8-12 Ann Intern Med Chou R. 157 719 2012 10.7326/0003-4819-157-10-201211200-00009 Chou R.; Cantor A.G.; Zakher B.; Bougatsos C.; Screening for HIV in pregnant women: systematic review to update the 2005 U.S. Preventive Services Task Force recommendation. Ann Intern Med 2012,157(10),719-728 J Clin Nurs Ahmad I. 26 3271 2017 10.1111/jocn.13706 Ahmad I.; Ali P.A.; Rehman S.; Talpur A.; Dhingra K.; Intimate partner violence screening in emergency department: a rapid review of the literature. J Clin Nurs 2017,26(21-22),3271-3285 Am J Prev Med Boudreaux E.D. 50 445 2016 10.1016/j.amepre.2015.09.029 Boudreaux E.D.; Camargo C.A.; Arias S.A.; Sullivan A.F.; Allen M.H.; Goldstein A.B.; Manton A.P.; Espinola J.A.; Miller I.W.; Improving Suicide Risk Screening and Detection in the Emergency Department. Am J Prev Med 2016,50(4),445-453 Addict Sci Clin Pract Hawk K. 13 18 2018 10.1186/s13722-018-0117-1 Hawk K.; D’Onofrio G.; Emergency department screening and interventions for substance use disorders. Addict Sci Clin Pract 2018,13(1),18 J Adolesc Health Langerman S.D. 65 543 2019 10.1016/j.jadohealth.2019.05.019 Langerman S.D.; Badolato G.M.; Rucker A.; Jarvis L.; Patel S.J.; Goyal M.K.; Acceptability of Adolescent Social and Behavioral Health Screening in the Emergency Department. J Adolesc Health 2019,65(4),543-548 Acta Paediatr Teeuw A.H. 108 300 2019 10.1111/apa.14495 Teeuw A.H.; Kraan R.B.J.; van Rijn R.R.; Bossuyt P.M.M.; Heymans H.S.A.; Screening for child abuse using a checklist and physical examinations in the emergency department led to the detection of more cases. Acta Paediatr 2019,108(2),300-313 Am J Emerg Med Jenkins W.D. 37 1196 2019 10.1016/j.ajem.2018.10.033 Jenkins W.D.; Chlamydia and gonorrhea screening in the emergency department setting: increasing evidence of utility and need for further research. Am J Emerg Med 2019,37(6),1196 PLoS One White D.A. 11 e0164831 2016 10.1371/journal.pone.0164831 White D.A.; Anderson E.S.; Pfeil S.K.; Deering L.J.; Todorovic T.; Trivedi T.K.; Hepatitis C.; Hepatitis C Virus Screening and Emergency Department Length of Stay. PLoS One 2016,11(10),e0164831 J Emerg Med Adler D. 57 836 2019 10.1016/j.jemermed.2019.07.021 Adler D.; Abar B.; Wood N.; Bonham A.; An Intervention to Increase Uptake of Cervical Cancer Screening Among Emergency Department Patients: Results of a Randomized Pilot Study. J Emerg Med 2019,57(6),836-843 QJM Fallon A. 111 151 2018 10.1093/qjmed/hcx242 Fallon A.; Kilbane L.; Briggs R.; Dyer A.; Nabeel S.; McElwaine P.; Collins R.; Coughlan T.; O’Neill D.; Ryan D.; Kennelly S.P.; Screening for frailty in older emergency department patients: the utility of the Survey of Health, Ageing and Retirement in Europe Frailty Instrument. QJM 2018,111(3),151-154 Acad Emerg Med Kaltiso S.O. 25 1193 2018 10.1111/acem.13497 Kaltiso S.O.; Greenbaum V.J.; Agarwal M.; McCracken C.; Zmitrovich A.; Harper E.; Simon H.K.; Evaluation of a screening tool for child sex trafficking among patients with high-risk chief complaints in a pediatric emergency department. Acad Emerg Med 2018,25(11),1193-1203 Emerg Med Australas Brock C. 30 864 2018 10.1111/1742-6723.13118 Brock C.; Yi Y.; Papaluca T.; Lucas B.; Angus P.W.; Taylor D.; Leung C.; Exploring the feasibility of targeted chronic hepatitis B screening in the emergency department: A pilot study. Emerg Med Australas 2018,30(6),864-866 Emerg Med Australas Lappin J.M. 30 648 2018 10.1111/1742-6723.12959 Lappin J.M.; Ayub M.H.; Rogers D.; Morgan M.; Kanyamibwa J.Y.; Shakeshaft A.; Routine screening and related interventions significantly improve the effectiveness of emergency department detection and management of alcohol withdrawal syndrome. Emerg Med Australas 2018,30(5),648-653 J Am Acad Nurse Pract Scott R.L. 23 493 2011 10.1111/j.1745-7599.2011.00636.x Scott R.L.; Cummings G.E.; Newburn-Cook C.; The feasibility and effectiveness of emergency department based hypertension screening: a systematic review. J Am Acad Nurse Pract 2011,23(9),493-500 NHS: London Health Programmes Quality and Safety Programme Emergency departments: Case for change NHS: London Health Programmes J Emerg Med Minassian A. 45 520 2013 10.1016/j.jemermed.2013.05.007 Minassian A.; Vilke G.M.; Wilson M.P.; Frequent emergency department visits are more prevalent in psychiatric, alcohol abuse, and dual diagnosis conditions than in chronic viral illnesses such as hepatitis and human immunodeficiency virus. J Emerg Med 2013,45(4),520-525 Ann Emerg Med Wu L.T. 60 172 2012 10.1016/j.annemergmed.2012.02.003 Wu L.T.; Swartz M.S.; Wu Z.; Mannelli P.; Yang C.; Blazer D.G.; Alcohol and drug use disorders among adults in emergency department settings in the United States. Ann Emerg Med 2012,60(2),172-80.e5 Emerg Med J Leaman A.M. 23 918 2006 10.1136/emj.2006.035980 Leaman A.M.; Rysdale E.; Webber R.; Use of the emergency department by Polish migrant workers. Emerg Med J 2006,23(12),918-919 J Emerg Nurs Grimm J.W. 35 127 2009 10.1016/j.jen.2008.08.018 Grimm J.W.; Wells J.L.; Illegal immigrants in the emergency department: an ethical dilemma for nurses? J Emerg Nurs 2009,35(2),127-128 Acad Emerg Med Salhi B.A. 25 577 2018 10.1111/acem.13358 Salhi B.A.; White M.H.; Pitts S.R.; Wright D.W.; Homelessness and emergency medicine: a review of the literature. Acad Emerg Med 2018,25(5),577-593 Subst Use Misuse Nambiar D. 53 457 2018 10.1080/10826084.2017.1341921 Nambiar D.; Spelman T.; Stoové M.; Dietze P.; Are people who inject drugs frequent users of emergency department services? a cohort study (2008-2013). Subst Use Misuse 2018,53(3),457-465 Am Family Phys Screening for HIV: Recommendation Statement Am Family Phys US Preventive Services Task Force2014: 89(8). Int J STD AIDS Gökengin D. 25 695 2014 10.1177/0956462414531244 Gökengin D.; Geretti A.M.; Begovac J.; Palfreeman A.; Stevanovic M.; Tarasenko O.; Radcliffe K.; 2014 European Guideline on HIV testing. Int J STD AIDS 2014,25(10),695-704 HIV Indicator Conditions: Guidance for Implementing HIV Testing in Adults in Health Care Settings 2015 HIV Indicator Conditions: Guidance for Implementing HIV Testing in Adults in Health Care Settings HIV in Europe Initiative2015 Curr HIV Res Hayes R. 9 429 2011 10.2174/157016211798038515 Hayes R.; Sabapathy K.; Fidler S.; Universal testing and treatment as an HIV prevention strategy: research questions and methods. Curr HIV Res 2011,9(6),429-445 MMWR Recomm Rep Branson B.M. 55 1 2006 Branson B.M.; Handsfield H.H.; Lampe M.A.; Janssen R.S.; Taylor A.W.; Lyss S.B.; Clark J.E.; Revised recommendations for HIV testing of adults, adolescents, and pregnant women in health-care settings. MMWR Recomm Rep Centers for Disease Control and Prevention (CDC)2006,55(RR-14),1-17 UK National Guidelines for HIV Testing 2008 British H. 2008 British H.; UK National Guidelines for HIV Testing 2008 BHIVA2008 HIV testing: increasing uptake among people who may have undiagnosed HIV 2016 HIV testing: increasing uptake among people who may have undiagnosed HIV National Institute for Health and Care Excellence (NICE)2016 Acad Emerg Med Haukoos J.S. 14 1149 2007 10.1197/j.aem.2007.07.015 Haukoos J.S.; Hopkins E.; Eliopoulos V.T.; Byyny R.L.; Laperriere K.A.; Mendoza M.X.; Thrun M.W.; Development and implementation of a model to improve identification of patients infected with HIV using diagnostic rapid testing in the emergency department. Acad Emerg Med Denver Emergency Department Rapid HIV Testing Study Group2007,14(12),1149-1157 Ann Emerg Med Schrantz S. J. 58 S85 2011 10.1016/j.annemergmed.2011.03.031 Schrantz S. J.; Babcock C. A.; Theodosis C.; Brown S.; Mercer S.; Pillow M. T.; A targeted, conventional assay, emergency department HIV testing program integrated with existing clinical procedures Ann Emerg Med 2011,58,S85-88e81 Ann Emerg Med Leblanc J. 72 41 2018 10.1016/j.annemergmed.2017.09.011 Leblanc J.; Hejblum G.; Costagliola D.; Durand-Zaleski I.; Lert F.; de Truchis P.; Verbeke G.; Rousseau A.; Piquet H.; Simon F.; Pateron D.; Simon T.; Crémieux A.C.; Targeted HIV screening in eight emergency departments: the DICI-VIH cluster randomized two-period crossover trial. Ann Emerg Med DICI-VIH (Dépistage Infirmier CIblé du VIH) Group2018,72(1),41-53.e9 Ann Emerg Med Lyons M.S. 46 22 2005 Lyons M.S.; Lindsell C.J.; Ledyard H.K.; Frame P.T.; Trott A.T.; Emergency department HIV testing and counseling: an ongoing experience in a low-prevalence area Ann Emerg Med 2005,46(1),22-28 J Acquir Immune Defic Syndr Lyons M.S. 64 315 2013 10.1097/QAI.0b013e3182a21611 Lyons M.S.; Lindsell C.J.; Ruffner A.H.; Wayne D.B.; Hart K.W.; Sperling M.I.; Trott A.T.; Fichtenbaum C.J.; Randomized comparison of universal and targeted HIV screening in the emergency department. J Acquir Immune Defic Syndr 2013,64(3),315-323 AIDS Patient Care STDS Christopoulos K.A. 25 439 2011 10.1089/apc.2011.0041 Christopoulos K.A.; Kaplan B.; Dowdy D.; Haller B.; Nassos P.; Roemer M.; Dowling T.; Jones D.; Hare C.B.; Testing and linkage to care outcomes for a clinician-initiated rapid HIV testing program in an urban emergency department. AIDS Patient Care STDS 2011,25(7),439-444 Ann Emerg Med Haukoos J.S. 61 353 2013 10.1016/j.annemergmed.2012.10.031 Haukoos J.S.; Hopkins E.; Bender B.; Sasson C.; Al-Tayyib A.A.; Thrun M.W.; Comparison of enhanced targeted rapid HIV screening using the Denver HIV risk score to nontargeted rapid HIV screening in the emergency department. Ann Emerg Med Denver Emergency Department HIV Testing Research Consortium2013,61(3),353-361 Acad Emerg Med Dowdy D.W. 18 745 2011 10.1111/j.1553-2712.2011.01110.x Dowdy D.W.; Rodriguez R.M.; Hare C.B.; Kaplan B.; Cost-effectiveness of targeted human immunodeficiency virus screening in an urban emergency department. Acad Emerg Med 2011,18(7),745-753 PLoS One Gillet C. 13 2018 10.1371/journal.pone.0190767 Gillet C.; Darling K.E.A.; Senn N.; Cavassini M.; Hugli O.; Targeted versus non-targeted HIV testing offered via electronic questionnaire in a Swiss emergency department: A randomized controlled study. PLoS One 2018,13(3) Worldviews Evid Based Nurs Leblanc J. 16 444 2019 10.1111/wvn.12393 Leblanc J.; Côté J.; Pagé M.G.; Piquet H.; Simon T.; Crémieux A.C.; Implementation of Nurse-Driven HIV Screening Targeting Key Populations in Emergency Departments: A Multilevel Analysis From the DICI-VIH Trial. Worldviews Evid Based Nurs DICI-VIH (Dépistage Infirmier CIblé du VIH) Group2019,16(6),444-453 Ann Emerg Med Hoot N.R. 52 126 2008 10.1016/j.annemergmed.2008.03.014 Hoot N.R.; Aronsky D.; Systematic review of emergency department crowding: causes, effects, and solutions. Ann Emerg Med 2008,52(2),126-136 Int Emerg Nurs Blackburn J. 42 30 2019 10.1016/j.ienj.2018.07.002 Blackburn J.; Ousey K.; Goodwin E.; Information and communication in the emergency department. Int Emerg Nurs 2019,42,30-35 CJEM McRae A.D. 20 443 2018 10.1017/cem.2017.434 McRae A.D.; Perry J.J.; Brehaut J.; Brown E.; Curran J.; Emond M.; Hohl C.; Taljaard M.; Stiell I.G.; Engaging emergency clinicians in emergency department clinical research. CJEM 2018,20(3),443-447 Emerg Med Australas Babl F.E. 31 4 2019 10.1111/1742-6723.13213 Babl F.E.; Curtis N.; Dalziel S.R.; Review article: A primer for clinical researchers in the emergency department: Part VII. Considering a research higher degree in emergency medicine: How does it work, where to start, what to consider. Emerg Med Australas 2019,31(1),4-10 J Acquir Immune Defic Syndr Smith MK 63 S187 2013 Smith MK; Rutstein SE; Powers KA; Fidler S; Miller WC; Eron JJ; Cohen MS; The detection and management of early HIV infection: a clinical and public health emergency J Acquir Immune Defic Syndr 2013,63(Suppl 2),S187-99 J Int AIDS Soc Rutstein S.E. 20 21579 2017 10.7448/IAS.20.1.21579 Rutstein S.E.; Ananworanich J.; Fidler S.; Johnson C.; Sanders E.J.; Sued O.; Saez-Cirion A.; Pilcher C.D.; Fraser C.; Cohen M.S.; Vitoria M.; Doherty M.; Tucker J.D.; Clinical and public health implications of acute and early HIV detection and treatment: a scoping review. J Int AIDS Soc 2017,20(1),21579 N Engl J Med Sanders G.D. 352 570 2005 10.1056/NEJMsa042657 Sanders G.D.; Bayoumi A.M.; Sundaram V.; Bilir S.P.; Neukermans C.P.; Rydzak C.E.; Douglass L.R.; Lazzeroni L.C.; Holodniy M.; Owens D.K.; Cost-effectiveness of screening for HIV in the era of highly active antiretroviral therapy. N Engl J Med 2005,352(6),570-585 New England Journal of Medicine Quinn TC 342 921 2000 Quinn TC; Wawer MJ; Sewankambo N; Serwadda D; Li C; Wabwire-Mangen F; Viral load and heterosexual transmission of human immunodeficiency virus type 1: Rakai Project Study Group New England Journal of Medicine 2000,342(13),921-930 J Int AIDS Soc Kroon E.D.M.B. 20 21708 2017 10.7448/IAS.20.1.21708 Kroon E.D.M.B.; Phanuphak N.; Shattock A.J.; Fletcher J.L.K.; Pinyakorn S.; Chomchey N.; Akapirat S.; de Souza M.S.; Robb M.L.; Kim J.H.; van Griensven F.; Ananworanich J.; Wilson D.P.; Acute HIV infection detection and immediate treatment estimated to reduce transmission by 89% among men who have sex with men in Bangkok. J Int AIDS Soc 2017,20(1),21708 Curr Opin HIV AIDS Miller W.C. 5 277 2010 10.1097/COH.0b013e32833a0d3a Miller W.C.; Rosenberg N.E.; Rutstein S.E.; Powers K.A.; Role of acute and early HIV infection in the sexual transmission of HIV. Curr Opin HIV AIDS 2010,5(4),277-282 Int J STD AIDS Bell S. 30 113 2019 10.1177/0956462418796445 Bell S.; Adamson J.; Martin F.; Doran T.; HIV testing amongst older sexual health clinic attendees in England: an epidemiological study. Int J STD AIDS 2019,30(2),113-119 Public Health Rep Campos-Outcalt D. 121 175 2006 10.1177/003335490612100212 Campos-Outcalt D.; Mickey T.; Weisbuch J.; Jones R.; Integrating routine HIV testing into a public health STD clinic. Public Health Rep 2006,121(2),175-180 BMJ Hamill M. 334 1352 2007 10.1136/bmj.39218.404201.94 Hamill M.; Burgoine K.; Farrell F.; Hemelaar J.; Patel G.; Welchew D.E.; Jaffe H.W.; Time to move towards opt-out testing for HIV in the UK. BMJ 2007,334(7608),1352-1354 Review of HIV epidemiology in London Review of HIV epidemiology in London Public Health England Euro Surveill Nick B. 24 1800377 2019 Nick B.; Sooria B.; Sarah P.; Sadna U.; Harris R.J.; Karim A.; Foster G.R.; Seroprevalence and demographic factors associated with hepatitis B, hepatitis C and HIV infection from a hospital emergency department testing programme 2015 to 2016. Euro Surveill 2019,24(27),1800377 Epidemiol Infect Cieply L. 147 e145 2019 10.1017/S0950268819000360 Cieply L.; Simmons R.; Ijaz S.; Kara E.; Rodger A.; Rosenberg W.; McGuinness A.; Mbisa J.L.; Ledesma J.; Ohemeng-Kumi N.; Dicks S.; Potts H.; Lattimore S.; Mandal S.; Seroprevalence of HCV, HBV and HIV in two inner-city London emergency departments. Epidemiol Infect 2019,147(e145),e145 Int J STD AIDS Hempling M.C. 27 1267 2016 10.1177/0956462415613727 Hempling M.C.; Zielicka-Hardy A.; Ellis J.P.; Majewska W.; Fida G.; Routine HIV testing in the Emergency Department: feasible and acceptable? Int J STD AIDS 2016,27(14),1267-1274 Epidemiol Infect Parry S. 146 1026 2018 10.1017/S0950268818000870 Parry S.; Bundle N.; Ullah S.; Foster G.R.; Ahmad K.; Tong C.Y.W.; Balasegaram S.; Orkin C.; Implementing routine blood-borne virus testing for HCV, HBV and HIV at a London Emergency Department - uncovering the iceberg? Epidemiol Infect 2018,146(8),1026-1035 HIV Med Bradshaw D. 19 52 2018 10.1111/hiv.12590 Bradshaw D.; Rae C.; Rayment M.; Turner N.; Turner R.; Pickard G.; Pillay K.; Roberts P.; Foxton M.; Sullivan A.K.; HIV/HCV/HBV testing in the emergency department: a feasibility and seroprevalence study. HIV Med 2018,19(Suppl. 1),52-57 HIV Med Bath R. 16 326 2015 10.1111/hiv.12216 Bath R.; Ahmad K.; Orkin C.; Routine HIV testing within the emergency department of a major trauma centre: a pilot study. HIV Med 2015,16(5),326-328 HIV Med Orkin C. 17 222 2016 10.1111/hiv.12364 Orkin C.; Flanagan S.; Wallis E.; Ireland G.; Dhairyawan R.; Fox J.; Nandwani R.; O’Connell R.; Lascar M.; Bulman J.; Reeves I.; Palfreeman A.; Foster G.R.; Ahmad K.; Anderson J.; Tong C.Y.; Lattimore S.; Incorporating HIV/hepatitis B virus/hepatitis C virus combined testing into routine blood tests in nine UK Emergency Departments: the “Going Viral” campaign. HIV Med 2016,17(3),222-230 Sex Transm Infect Dhairyawan R. 92 557 2016 10.1136/sextrans-2016-052742 Dhairyawan R.; O’Connell R.; Flanagan S.; Wallis E.; Orkin C.; Linkage to care after routine HIV, hepatitis B J Viral Hepat Hopkins M.J. 27 88 2020 10.1111/jvh.13197 Hopkins M.J.; Todd S.; Beadsworth M.; Anderson C.; Mohamed Z.; Muir D.; Vivancos R.; Brown A.S.; Ruf M.; Chawla A.; Consistent high prevalence of undiagnosed blood-borne virus infection in patients attending large urban emergency departments in England. J Viral Hepat 2020,27(1),88-91 Ann Emerg Med Kecojevic A 58 S151 2011 Kecojevic A; Lindsell CJ; Lyons MS; Public Health and Clinical Impact of Increasing Emergency Department-Based HIV Testing: Perspectives From the 2007 Conference of the National Emergency Department HIV Testing Consortium Ann Emerg Med 2011,58(Suppl 1),S151-S159 Ann Emerg Med Irvin C.B. 49 722 2007 10.1016/j.annemergmed.2007.03.011 Irvin C.B.; Flagel B.T.; Fox J.M.; The emergency department is not the ideal place for routine HIV testing. Ann Emerg Med 2007,49(5),722-722 Acad Emerg Med Kelen G.D. 15 194 2008 10.1111/j.1553-2712.2008.00068.x Kelen G.D.; Public health initiatives in the emergency department: not so good for the public health? Acad Emerg Med 2008,15(2),194-197 HIV Med Rayment M. 14 6 2013 10.1111/hiv.12069 Rayment M.; Rae C.; Ghooloo F.; Doku E.; Hardie J.; Finlay S.; Gidwani S.; Atkins M.; Roberts P.; Sullivan A.K.; Routine HIV testing in the emergency department: tough lessons in sustainability. HIV Med 2013,14(Suppl. 3),6-9 Arch Intern Med d’Almeida K.W. 172 12 2012 10.1001/archinternmed.2011.535 d’Almeida K.W.; Kierzek G.; de Truchis P.; Le Vu S.; Pateron D.; Renaud B.; Semaille C.; Bousquet V.; Simon F.; Guillemot D.; Lert F.; Crémieux A.C.; Modest public health impact of nontargeted human immunodeficiency virus screening in 29 emergency departments. Arch Intern Med Emergency Department HIV-Screening Group2012,172(1),12-20 Arch Intern Med Haukoos J.S. 172 20 2012 10.1001/archinternmed.2011.538 Haukoos J.S.; The impact of nontargeted HIV screening in emergency departments and the ongoing need for targeted strategies. Arch Intern Med 2012,172(1),20-22 PLOS ONE mez-Ayerbe Cristina Go 2019 mez-Ayerbe Cristina Go; Impact of a structured HIV testing program in a hospital emergency department and a primary care center PLOS ONE 2019 Ann Emerg Med Hudepohl N.J. 58 S140 2011 10.1016/j.annemergmed.2011.03.038 Hudepohl N.J.; Lindsell C.J.; Hart K.W.; Ruffner A.H.; Trott A.T.; Fichtenbaum C.J.; Lyons M.S.; Effect of an emergency department HIV testing program on the proportion of emergency department patients who have been tested. Ann Emerg Med 2011,58(1)(Suppl. 1),S140-S144

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DOI https://dx.doi.org/10.2174/1570162X18666201123113905	Print ISSN 1570-162X
Publisher Name Bentham Science Publisher	Online ISSN 1873-4251

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The Role of Targeted HIV Screening in the Emergency Department: A Scoping Review

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