Abstract
Hormone-sensitive breast cancers correspond to breast tumors with the existence of estrogen and progesterone in the tumor issue. The hormones estrogen and progesterone may in some circumstance promote the growth of breast cancers. Therefore, compounds targeting hormone-sensitive breast cancers have attracted considerable interest from synthetic organic chemists. In the past two decades, numerous compounds have thus been designed and synthesized to investigate their anti-breast cancer activities. In this review, some recent synthetic endeavor in the past five years towards compounds targeting hormone-sensitive breast cancers, especially estrogenreceptor positive breast cancers, are summarized.
Keywords: Anti-breast cancer, Estrogen-receptor, ER-positive, hormone-sensitive, MCF-7, stereo-control, synthesis, total synthesis.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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