Novel Anti-inflammatory Interleukin-35 as an Emerging Target for Antiatherosclerotic Therapy

Title:Novel Anti-inflammatory Interleukin-35 as an Emerging Target for Antiatherosclerotic Therapy

Volume: 21 Issue: 9

Author(s): Yuri V. Bobryshev, Igor A. Sobenin, Alexander N. Orekhov and Dimitry A. Chistiakov

Affiliation:

Keywords: Inflammation, interleukin-35, atherosclerosis, atherogenesis, arteries, anti-atherosclerotic therapy.

Abstract: Atherosclerosis has been widely recognized as a slow progressing inflammatory disease of the aorta and other large caliber arterial vessels. Accumulating evidence suggest that interleukin (IL)-35 can represent an attractive target for future anti-atherosclerotic therapy due to several atheroprotective properties. First, immunosuppressive and anti-inflammatory activity of this cytokine could be beneficial against vascular inflammation. Second, IL-35 can suppress a variety of T cells including proinflammatory Th1 and Th17 cells and probably dendritic cells. Third, IL-35 supports proliferation of regulatory T cells (Tregs), increases their inhibitory function, and induces a new set of Tregs called inducible IL-35-producing Tregs (iTr35 cells). Fourth, this cytokine promotes production of antiinflammatory cytokines such as IL-10 and down-regulates expression of proinflammatory cytokines such as IL-17. Finally, IL-35 is inducible. The fact that IL-35 could be induced by simple compounds such as chemical chaperons may provide advances in developing new efficient strategies for treatment of atherosclerosis. However, it is necessary to test IL-35-inducing factors in order to understand mechanisms of induction and then select the most optimal one. Probably, constructing of humanized antibodies that mimic IL-35 function may provide benefits for advanced atheroprotective therapy.

Cite this article as:

Bobryshev V. Yuri, Sobenin A. Igor, Orekhov N. Alexander and Chistiakov A. Dimitry, Novel Anti-inflammatory Interleukin-35 as an Emerging Target for Antiatherosclerotic Therapy, Current Pharmaceutical Design 2015; 21 (9) . https://dx.doi.org/10.2174/1381612820666141014123810