Abstract
Cryptotanshinone is one of the major tanshinones isolated from the roots of the plant Salvia miltiorrhiza Bunge (Danshen). Danshen has been widely used in traditional Chinese medicine for treatment of a variety of diseases, including coronary artery disease, acute ischemic stroke, hyperlipidemia, chronic renal failure, chronic hepatitis, and Alzheimer's disease, showing no serious adverse effects. Recent studies have shown that cryptotanshinone not only possesses the potential for treatment and prevention of the above-mentioned diseases, but also is a potent anticancer agent. Here we briefly summarize the physical and chemical properties and the pharmacokinetic profiles of cryptotanshinone, and then comprehensively review its anticancer activities as well as the underlying mechanisms.
Keywords: Cryptotanshinone, tanshinones, cancer, cell proliferation, cell death, mTOR.
Anti-Cancer Agents in Medicinal Chemistry
Title:Molecular Evidence of Cryptotanshinone for Treatment and Prevention of Human Cancer
Volume: 13 Issue: 7
Author(s): Wenxing Chen, Yin Lu, Guangying Chen and Shile Huang
Affiliation:
Keywords: Cryptotanshinone, tanshinones, cancer, cell proliferation, cell death, mTOR.
Abstract: Cryptotanshinone is one of the major tanshinones isolated from the roots of the plant Salvia miltiorrhiza Bunge (Danshen). Danshen has been widely used in traditional Chinese medicine for treatment of a variety of diseases, including coronary artery disease, acute ischemic stroke, hyperlipidemia, chronic renal failure, chronic hepatitis, and Alzheimer's disease, showing no serious adverse effects. Recent studies have shown that cryptotanshinone not only possesses the potential for treatment and prevention of the above-mentioned diseases, but also is a potent anticancer agent. Here we briefly summarize the physical and chemical properties and the pharmacokinetic profiles of cryptotanshinone, and then comprehensively review its anticancer activities as well as the underlying mechanisms.
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Cite this article as:
Chen Wenxing, Lu Yin, Chen Guangying and Huang Shile, Molecular Evidence of Cryptotanshinone for Treatment and Prevention of Human Cancer, Anti-Cancer Agents in Medicinal Chemistry 2013; 13 (7) . https://dx.doi.org/10.2174/18715206113139990115
DOI https://dx.doi.org/10.2174/18715206113139990115 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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