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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Synthesis and Anti Cervical Cancer Activity of Novel 5H-Thiochromeno [4,3-d]pyrimidines

Author(s): Dhananjay Pandya and Yogesh Naliapara*

Volume 17, Issue 4, 2020

Page: [294 - 302] Pages: 9

DOI: 10.2174/1570178616666190705152116

Price: $65

Abstract

A series of novel 5H-Thiochromeno[4,3-d]pyrimidine derivatives were synthesized, purified and characterized by different spectroscopy techniques such as 1H NMR, 13C NMR, Mass and Elemental Analysis. The new compounds were evaluated for their anti-cervical cancer activity on Human Cervical Cell Line HeLa. They were found to be potent anti-cervical cancer agents with GI50 values less than 10 μg/mL with respect to positive control drug Adriamycin.

Keywords: 5H-Thiochromeno[4, 3-d]pyrimidine, benzothiopyranopyrimidine, anti-cervical cancer activity, adriamycin, human cervical cancer cell line HeLa. Spectroscopy, elemental analysis.

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