Abstract
The Drug Discovery Portal (DDP) is a research initiative based at the University of Strathclyde in Glasgow, Scotland. It was initiated in 2007 by a group of researchers with expertise in virtual screening. Academic research groups in the university working in drug discovery programmes estimated there was a historical collection of physical compounds going back 50 years that had never been adequately catalogued. This invaluable resource has been harnessed to form the basis of the DDP library, and has attracted a highpercentage uptake from universities and research groups internationally. Its unique attributes include the diversity of the academic database, sourced from synthetic, medicinal and phytochemists working in academic laboratories and the ability to link biologists with appropriate chemical expertise through a target-matching virtual screening approach, and it has resulted in seven emerging hit development programmes between international contributors.
Keywords: Virtual screening, academic drug discovery, natural products, chemical diversity
Current Pharmaceutical Design
Title: The Drug Discovery Portal: A Computational Platform for Identifying Drug Leads from Academia
Volume: 16 Issue: 15
Author(s): Rachel L. Clark, Blair F. Johnston, Simon P. Mackay, Catherine J. Breslin, Murray N. Robertson, Oliver B. Sutcliffe, Mark J. Dufton and Alan L. Harvey
Affiliation:
Keywords: Virtual screening, academic drug discovery, natural products, chemical diversity
Abstract: The Drug Discovery Portal (DDP) is a research initiative based at the University of Strathclyde in Glasgow, Scotland. It was initiated in 2007 by a group of researchers with expertise in virtual screening. Academic research groups in the university working in drug discovery programmes estimated there was a historical collection of physical compounds going back 50 years that had never been adequately catalogued. This invaluable resource has been harnessed to form the basis of the DDP library, and has attracted a highpercentage uptake from universities and research groups internationally. Its unique attributes include the diversity of the academic database, sourced from synthetic, medicinal and phytochemists working in academic laboratories and the ability to link biologists with appropriate chemical expertise through a target-matching virtual screening approach, and it has resulted in seven emerging hit development programmes between international contributors.
Export Options
About this article
Cite this article as:
L. Clark Rachel, F. Johnston Blair, P. Mackay Simon, J. Breslin Catherine, N. Robertson Murray, B. Sutcliffe Oliver, J. Dufton Mark and L. Harvey Alan, The Drug Discovery Portal: A Computational Platform for Identifying Drug Leads from Academia, Current Pharmaceutical Design 2010; 16 (15) . https://dx.doi.org/10.2174/138161210791164018
DOI https://dx.doi.org/10.2174/138161210791164018 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Pharmacological Overview and Future Perspectives of Cholinergic Therapy in Alzheimers Disease
Current Drug Therapy Coagulation Disorders in Acute Lung Injury
Current Respiratory Medicine Reviews Meet Our Editorial Board Member
Current Molecular Pharmacology In Vivo Uptake of β-Amyloid by Non-Plaque Associated Microglia
Current Alzheimer Research HMG-CoA Reductase Inhibitors (Statins) and their Drug Interactions Involving CYP Enzymes, P-glycoprotein and OATP Transporters-An Overview
Current Drug Metabolism Prevalence of Neuropsychiatric Symptoms in Mild Cognitive Impairment and Alzheimers Disease, and its Relationship with Cognitive Impairment
Current Alzheimer Research Strategies to Overcome or Circumvent P-Glycoprotein Mediated Multidrug Resistance
Current Medicinal Chemistry Anti-Inflammatory Effects of Antidepressants: Possibilities for Preventives Against Alzheimers Disease
Central Nervous System Agents in Medicinal Chemistry Emerging Evidence for the Role of Neurotransmitters in the Modulation of T Cell Responses to Cognate Ligands
Central Nervous System Agents in Medicinal Chemistry <i>In Vivo/Ex Vivo</i> EPR Investigation of the Brain Redox Status and Blood-Brain Barrier Integrity in the 5xFAD Mouse Model of Alzheimer's Disease
Current Alzheimer Research Melanocortin Receptor Type 3 as a Potential Target for Anti-Inflammatory Therapy
Current Drug Targets - Inflammation & Allergy Targeted Inhibition of Rictor/mTORC2 in Cancer Treatment: A New Era after Rapamycin
Current Cancer Drug Targets The Therapeutic Community for the Adolescent Substance Abuser
Adolescent Psychiatry Pharmacological Applications of Lignins and Lignins Related Compounds: An Overview
Current Organic Chemistry Airway Remodeling: Effect of Current and Future Asthma Therapies
Current Respiratory Medicine Reviews Involvement of GABA<sub>B</sub> Receptor Signaling in Antipsychotic-like Action of the Novel Orthosteric Agonist of the mGlu<sub>4</sub> Receptor, LSP4-2022
Current Neuropharmacology Methodologic Issues in the Validation of Putative Biomarkers and Surrogate Endpoints in Treatment Evaluation for Systemic Lupus Erythematosus
Endocrine, Metabolic & Immune Disorders - Drug Targets Analysis of Heart Rate Variability and Implication of Different Factors on Heart Rate Variability
Current Cardiology Reviews Aberrant Expression of MicroRNAs in B-cell Lymphomas
MicroRNA Molecular Targets and Angiogenesis in Renal Cell Carcinoma, A Multitarget Approach: Mini Review
Current Drug Targets