Abstract
The search for new antifungal agents was essential because of opportunistic infections in immunocompromised individuals and the development of resistance to currently used agents. Bryophytes offer a rich source of rare and structurally unique molecules and can serve as a reserve of potentially antifungal compounds for further development as pharmaceuticals. This minireview covered the chemical and biological research of Chinese bryophytes recently finished in our laboratory. Totally about 120 compounds have been isolated and identified from 17 bryophyte species collected from North to South of China. The antifungal effect of these isolated compounds and their reversal of resistance of Candida albicans to fluconazole were evaluated. The possible reversal mechanisms were also preliminarily tested.
Current Organic Chemistry
Title: Chemical Constituents from the Chinese Bryophytes and Their Reversal of Fungal Resistance
Volume: 12 Issue: 8
Author(s): Chunfeng Xie and Hongxiang Lou
Affiliation:
Abstract: The search for new antifungal agents was essential because of opportunistic infections in immunocompromised individuals and the development of resistance to currently used agents. Bryophytes offer a rich source of rare and structurally unique molecules and can serve as a reserve of potentially antifungal compounds for further development as pharmaceuticals. This minireview covered the chemical and biological research of Chinese bryophytes recently finished in our laboratory. Totally about 120 compounds have been isolated and identified from 17 bryophyte species collected from North to South of China. The antifungal effect of these isolated compounds and their reversal of resistance of Candida albicans to fluconazole were evaluated. The possible reversal mechanisms were also preliminarily tested.
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Cite this article as:
Xie Chunfeng and Lou Hongxiang, Chemical Constituents from the Chinese Bryophytes and Their Reversal of Fungal Resistance, Current Organic Chemistry 2008; 12 (8) . https://dx.doi.org/10.2174/138527208784577385
DOI https://dx.doi.org/10.2174/138527208784577385 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
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