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Review Article

多形性胶质母细胞瘤和纳米药物载体的最新研究进展

卷 26, 期 31, 2019

页: [5862 - 5874] 页: 13

弟呕挨: 10.2174/0929867325666180514113136

价格: $65

摘要

多形胶质母细胞瘤（GBM）是最常见的神经胶质瘤，预后较差。 GBM的主要治疗方法是化学疗法，但由于治疗耐药性，GBM的平均存活率仍不能令人满意。 受血脑屏障（BBB）限制的通透性差和胶质母细胞瘤干细胞（GSC）的存在仍然是化疗的两个问题。 近年来，纳米载体由于其在自组装，生物安全，释放可控性和BBB渗透性方面的优势而在GBM的研究中引起了广泛的关注，使其成为有望用于GBM的候选药物。 本文旨在回顾BBB和GSC的生物学特征，以及纳米药物递送系统的新发展，以促进我们对GBM靶向治疗的理解。

关键词: 多形性胶质母细胞瘤，脑血屏障，胶质母细胞瘤干细胞，纳米载体，脂质，金，靶向治疗。

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