Physiological Functions of Presenilins; Beyond γ-Secretase

Title:Physiological Functions of Presenilins; Beyond γ-Secretase

Volume: 15 Issue: 11

Author(s): Ibolya Stiller, Beata Lizak and Gabor Banhegyi

Affiliation:

Keywords: Autophagy, Ca²⁺ signaling, presenilin, ER stress, γ-secretase, neurodegenerative disease.

Abstract: Presenilin (PS) was identified in screens for mutations causing the early onset forms of familial Alzheimer's disease (FAD) in 1995. As catalytic units of the γ-secretase complex, presenilins participate in the processing of amyloid beta protein (Aβ), the main component of deposits in brain of patients with AD. The more than 90 substrates of γ-secretase isolated so far demonstrate its contribution to wide range of cellular processes and signaling events. However, recent findings have revealed numerous γ-secretase-independent presenilin functions, including involvement in calcium homeostasis, endoplasmic reticulum (ER) stress and autophagy. This mini-review attempts to summarize the multiple physiological and pathological functions of presenilin.

Cite this article as:

Stiller Ibolya, Lizak Beata and Banhegyi Gabor, Physiological Functions of Presenilins; Beyond γ-Secretase, Current Pharmaceutical Biotechnology 2014; 15 (11) . https://dx.doi.org/10.2174/1389201015666141122204139