Abstract
The prognosis for malignant gliomas remains poor despite multimodality therapy. An increased understanding of the molecular pathogenesis involved in glioma development and growth has resulted in development of agents that specifically target these molecular processes and pathways. Except for inhibitors of the vascular endothelial growth factor pathway, results from most single agent trials have been modest at best. Tailoring therapy to the individual patients is an attractive strategy although most studies have failed to determine predictive biomarkers. Numerous novel agents, multitargeted agents, and combination therapies are now in clinical trials for malignant glioma.
Keywords: Targeted therapy, malignant glioma, angiogenesis, clinical trials, multi-targeted therapy, "malignant gliomas", cellular signaling kinases
Current Signal Transduction Therapy
Title:Application of Targeted Therapy to Malignant Gliomas and Response to Treatment
Volume: 8 Issue: 1
Author(s): Eudocia Q. Lee, Andrew D. Norden, Jan Drappatz and Patrick Y. Wen
Affiliation:
Keywords: Targeted therapy, malignant glioma, angiogenesis, clinical trials, multi-targeted therapy, "malignant gliomas", cellular signaling kinases
Abstract: The prognosis for malignant gliomas remains poor despite multimodality therapy. An increased understanding of the molecular pathogenesis involved in glioma development and growth has resulted in development of agents that specifically target these molecular processes and pathways. Except for inhibitors of the vascular endothelial growth factor pathway, results from most single agent trials have been modest at best. Tailoring therapy to the individual patients is an attractive strategy although most studies have failed to determine predictive biomarkers. Numerous novel agents, multitargeted agents, and combination therapies are now in clinical trials for malignant glioma.
Export Options
About this article
Cite this article as:
Q. Lee Eudocia, D. Norden Andrew, Drappatz Jan and Y. Wen Patrick, Application of Targeted Therapy to Malignant Gliomas and Response to Treatment, Current Signal Transduction Therapy 2013; 8 (1) . https://dx.doi.org/10.2174/1574362411308010004
DOI https://dx.doi.org/10.2174/1574362411308010004 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Reflecting Back to Bring Nitric Oxide Research to the Laboratory
Current Medicinal Chemistry Preclinical Molecular Imaging of the Translocator Protein (TSPO) in a Metastases Model Based on Breast Cancer Xenografts Propagated in the Murine Brain
Current Molecular Medicine Peptide Self-Assemblies for Drug Delivery
Current Topics in Medicinal Chemistry Bugs and Drugs: Oncolytic Virotherapy in Combination with Chemotherapy
Current Pharmaceutical Biotechnology Strategies on the Development of Small Molecule Anticancer Drugs for Targeted Therapy
Mini-Reviews in Medicinal Chemistry Therapeutic Challenges in Neuroendocrine Tumors
Anti-Cancer Agents in Medicinal Chemistry Cannabinoids and Sensory Neurones
Current Neuropharmacology Preparation and Biodistribution of Technetium-99m-Labeled Bis- Misonidazole (MISO) as an Imaging Agent for Tumour Hypoxia
Medicinal Chemistry Gene Therapy and Biologic Therapy with Interleukin?4
Current Gene Therapy Ex Vivo Proton NMR Analysis and Characterization of Thymus Lipid Metabolites and their Variation with Age in C57BL/6 Mice
Current Aging Science The Many Faces of MTA3 Protein in Normal Development and Cancers
Current Protein & Peptide Science The Role of Melanocortin Peptides and Receptors in Regulation of Energy Balance
Current Pharmaceutical Design Scorpion Toxin Polyptides as Therapeutic Agents: An Overview
Protein & Peptide Letters Neuropilin Signalling in Vascular Development and Pathology
Current Angiogenesis (Discontinued) Exploration of Chemical Space Based on 4-Anilinoquinazoline
Current Medicinal Chemistry Dysfunction of Mitochondrial ATP Production As a Target for Personalized Cancer Therapy
Current Pharmacogenomics and Personalized Medicine Endocannabinoids and Their Receptors: Physiology, Pathology and Pharmacology
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) The Quest for a Tumor Suppressor Gene Phenotype
Current Molecular Medicine Gold Nanoparticle-Based Drug Delivery Platform for Antineoplastic Chemotherapy
Current Drug Metabolism Targeting Aberrant TGF-β Signaling in Pre-Clinical Models of Cancer
Anti-Cancer Agents in Medicinal Chemistry