Abstract
Background: Nowadays, nitrones are the most used spin traps to characterize free radicals in biological systems due to the versatility and variety depending on the types of radicals to study and that the halflives of the species studied and/or detected increase considerably. In recent years, nitrones have been studied not only as free radical spin traps. Moreover, nitrones have been employed as therapeutic agents; in particular, those spin traps that are derived from α-phenyl-N-tert-butylnitrone (PBN). Nitrones as therapeutics agents have been used in the treatment of diseases related to oxidative stress such as neurodegeneration, cardiovascular disease and cancer.
Conclusion: In this review, we focus mainly on those studies where nitrones have been used as potential therapeutic agents in diseases such as cancer, neurodegenerative, acoustic trauma and others. In addition, we have shown that they continue to be a potent and important tool as radical spin trap as well as their use as therapeutic agent
Keywords: Nitrone, therapeutics, spin traps, cancer, neuroprotective, PBN, NXY-059.
Graphical Abstract
Current Organic Chemistry
Title:Nitrones: A Potential New Alternative as Therapeutic Agents
Volume: 21 Issue: 20
Author(s): German Barriga-Gonzalez*, Carolina Aliaga, Claudio Olea-Azar, Maria C. Zuniga-Lopez, Mercedes Gonzalez and Hugo Cerecetto
Affiliation:
- Universidad de Santiago de Chile, Facultad de Quimica y Biologia, Departamento de Ciencias del Ambiente, Av. Libertador Bernardo O'Higgins 3363, Santiago,Chile
Keywords: Nitrone, therapeutics, spin traps, cancer, neuroprotective, PBN, NXY-059.
Abstract: Background: Nowadays, nitrones are the most used spin traps to characterize free radicals in biological systems due to the versatility and variety depending on the types of radicals to study and that the halflives of the species studied and/or detected increase considerably. In recent years, nitrones have been studied not only as free radical spin traps. Moreover, nitrones have been employed as therapeutic agents; in particular, those spin traps that are derived from α-phenyl-N-tert-butylnitrone (PBN). Nitrones as therapeutics agents have been used in the treatment of diseases related to oxidative stress such as neurodegeneration, cardiovascular disease and cancer.
Conclusion: In this review, we focus mainly on those studies where nitrones have been used as potential therapeutic agents in diseases such as cancer, neurodegenerative, acoustic trauma and others. In addition, we have shown that they continue to be a potent and important tool as radical spin trap as well as their use as therapeutic agent
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Cite this article as:
Barriga-Gonzalez German*, Aliaga Carolina, Olea-Azar Claudio, Zuniga-Lopez C. Maria, Gonzalez Mercedes and Cerecetto Hugo, Nitrones: A Potential New Alternative as Therapeutic Agents, Current Organic Chemistry 2017; 21 (20) . https://dx.doi.org/10.2174/1385272821666170228131324
DOI https://dx.doi.org/10.2174/1385272821666170228131324 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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