From Ocean to Bedside: the Therapeutic Potential of Molluscan Hemocyanins

Title:From Ocean to Bedside: the Therapeutic Potential of Molluscan Hemocyanins

Volume: 25 Issue: 20

Author(s): Negar Talaei Zanjani, Monica Miranda Saksena, Fariba Dehghani*Anthony L. Cunningham *

Affiliation:

• School of Chemical and Biomolecular Engineering, Faculty of Engineering & IT, The University of Sydney, Sydney,Australia

• Centre for Virus Research, Westmead Institute for Medical Research, The University of Sydney, Sydney,Australia

Keywords: Hemocyanin, mollusc, mechanism of action, antiviral activity, immunotherapy, cancer vaccines.

Abstract: Hemocyanins are large and versatile glycoproteins performing various immunological and biological functions in many marine invertebrates including arthropods and molluscs. This review discusses the various pharmacological applications of mollusc hemocyanin such as antiviral activity, immunostimulatory and anticancer properties that have been reported in the literature between the years 2000 and 2016. Emphasis is placed on a better mechanistic understanding of hemocyanin as a therapeutic agent. Elucidation of the mechanism of action is essential to improve the clinical efficacy and for a better understanding of some endogenous immunological functions of this complex glycoprotein.

Cite this article as:

Zanjani Talaei Negar , Saksena Miranda Monica, Dehghani Fariba *, Cunningham L. Anthony *, From Ocean to Bedside: the Therapeutic Potential of Molluscan Hemocyanins, Current Medicinal Chemistry 2018; 25 (20) . https://dx.doi.org/10.2174/0929867324666170502124227