Abstract
With a number of formulations currently in clinical trials, the interest in polymer micelles as drug carriers in unlikely to subside. Historically, linear diblock copolymers have been used as the building blocks for micelle preparation. Yet, recent advances in polymer chemistry have meant that a wider variety of polymer architectures and compositions have become available and been trialed for pharmaceutical applications. This mini-review aims to provide an overview of recent, exciting developments in triblock, graft and hyperbranched polymer chemistries that may change the way polymeric micelles drug formulations are prepared.
Keywords: Micelles, Polymers, Drug formulation, Drug delivery, Onion-like micelles, Unimolecular micelles.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:Thinking Outside the ‘Block’: Alternative Polymer Compositions for Micellar Drug Delivery
Volume: 15 Issue: 22
Author(s): Marie-Christine Jones
Affiliation:
Keywords: Micelles, Polymers, Drug formulation, Drug delivery, Onion-like micelles, Unimolecular micelles.
Abstract: With a number of formulations currently in clinical trials, the interest in polymer micelles as drug carriers in unlikely to subside. Historically, linear diblock copolymers have been used as the building blocks for micelle preparation. Yet, recent advances in polymer chemistry have meant that a wider variety of polymer architectures and compositions have become available and been trialed for pharmaceutical applications. This mini-review aims to provide an overview of recent, exciting developments in triblock, graft and hyperbranched polymer chemistries that may change the way polymeric micelles drug formulations are prepared.
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Cite this article as:
Jones Marie-Christine, Thinking Outside the ‘Block’: Alternative Polymer Compositions for Micellar Drug Delivery, Current Topics in Medicinal Chemistry 2015; 15 (22) . https://dx.doi.org/10.2174/1568026615666150605114954
DOI https://dx.doi.org/10.2174/1568026615666150605114954 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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