贝沙罗汀-类维生素A药物与阿尔茨海默症中Aβ肽之间的可能分子反应：一个对接研究

Title:Possible Molecular Interactions of Bexarotene - A Retinoid Drug and Alzheimer's Aβ Peptide: A Docking Study

Volume: 14 Issue: 3

Author(s): Zeenat Mirza, Mohd Amin Beg.

Affiliation:

关键词: 阿尔茨海默症，淀粉样β肽，贝沙罗丁，对接，相互作用

摘要: Background: Alzheimer’s disease (AD) pathogenesis is primarily hallmarked by the production and accumulation of amyloid beta (Aβ) peptide. Along with the understanding of the neurodegenerative disease progression and its pathophysiological mechanisms, development of anti-Aβ targeted effective therapeutics is essential for AD management. Numerous therapeutic approaches targeting the production, toxicity and removal of Aβ are being attempted worldwide. Prime need is to design inhibitors which can slow down the Aβ aggregation process in a physiological environment. Bexarotene (targretin) is the first of the U.S. Food and Drug Administration approved oral retinoid X receptors (RXR)-selective retinoids, or rexinoids. It is effectively used for the treatment of advanced, refractory cutaneous T cell lymphoma, and also reportedly reduces Aβ levels in AD mouse models. Administration of bexarotene facilitates intracellular Aβ clearance via RXR regulated apolipoprotein E (ApoE) production.

Cite this article as:

Zeenat Mirza, Mohd Amin Beg. , Possible Molecular Interactions of Bexarotene - A Retinoid Drug and Alzheimer's Aβ Peptide: A Docking Study, Current Alzheimer Research 2017; 14 (3) . https://dx.doi.org/10.2174/1567205013666161114115344