用于口服药物递送的聚合物生物材料和脂质基纳米颗粒

Title:Polymeric Biomaterial and Lipid Based Nanoparticles for Oral Drug Delivery

Volume: 24 Issue: 22

关键词: 口服递送，聚合物纳米粒子，脂质纳米粒子，生物屏障，生物利用度

摘要: Background: Oral drug delivery is widespread owing to its non-invasive nature which complements high patient compliance. However, the drug administration via oral route is quite challenging due to the presence of the biochemical barriers which hinders the uptake as well as access to blood stream. Apart from that, stability, poor solubility and bioavailability of administered drug via the gastrointestinal (GI) tract are also exigent. Till now various oral formulations were developed which releases the drug in a timely manner but lacks appropriate therapeutic concentration.

Objective: Recently nanoparticles based drug delivery system has emerged as prominent strategy for optimizing the oral drug delivery and maximizing the treatment efficiency. Besides, different strategic polymeric nanoparticles are engineered for interaction both at extracellular and intracellular levels with gastrointestinal mucosa.

Methods: The review article focuses on the polymeric and lipid based various nanocarriers that have been widely studied for the enhanced oral drug delivery of different therapeutic molecules and addresses recent progress of biocompatible and biodegradable polymeric nanoparticles approach for its improvement.

Conclusion: The progress of numerous oral nanoparticulate drug delivery vehicles will be immensely helpful to improve therapeutic efficacy with reduced adverse side effects. Unlike other forms of administration, it will have better patient compliance and soothing effect. The oral drug delivery will certainly play a pivotal role soon in expanding the clinical repertoire and applications.

Cite this article as:

Polymeric Biomaterial and Lipid Based Nanoparticles for Oral Drug Delivery, Current Medicinal Chemistry 2017; 24 (22) . https://dx.doi.org/10.2174/0929867323666161028160004

DOI https://dx.doi.org/10.2174/0929867323666161028160004	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X