Abstract
This review overviews the advances in the chemistry of bismuth-containing heterocyclic compounds during the last decade. Some new types of bismuth-containing heterocyclic systems containing nitrogen, oxygen, sulfur and/or phosphorus in addition to bismuth have been synthesized. 5,6,7,12-Tetrahydrodibenz[c,f][1,5]azabismocine derivatives were the most extensively studied bismuthcontaining heterocyclic compounds during the last decade, and a number of new compounds were synthesized. Their application to organic synthesis has shown that they are useful as reagents for the cross-coupling reaction with organic halides and as Lewis acid catalysts. Also they were used for the fixation of CO2. Some pentavalent bismuth-containing heterocyclic compounds were found to be useful in organic synthesis. Biological activity of some of bismuth-containing heterocyclic compounds was studied and found to show antimicrobial, antibacterial, antifungal, and anticancer activities.
Keywords: Bismuth, Heterocyclic Compounds, Hypervalent Compounds, Organic Synthesis, Biological Activities
Current Organic Chemistry
Title: Recent Advances in the Synthesis and Application of Bismuth-Containing Heterocyclic Compounds
Volume: 15 Issue: 5
Author(s): Shigeru Shimada
Affiliation:
Keywords: Bismuth, Heterocyclic Compounds, Hypervalent Compounds, Organic Synthesis, Biological Activities
Abstract: This review overviews the advances in the chemistry of bismuth-containing heterocyclic compounds during the last decade. Some new types of bismuth-containing heterocyclic systems containing nitrogen, oxygen, sulfur and/or phosphorus in addition to bismuth have been synthesized. 5,6,7,12-Tetrahydrodibenz[c,f][1,5]azabismocine derivatives were the most extensively studied bismuthcontaining heterocyclic compounds during the last decade, and a number of new compounds were synthesized. Their application to organic synthesis has shown that they are useful as reagents for the cross-coupling reaction with organic halides and as Lewis acid catalysts. Also they were used for the fixation of CO2. Some pentavalent bismuth-containing heterocyclic compounds were found to be useful in organic synthesis. Biological activity of some of bismuth-containing heterocyclic compounds was studied and found to show antimicrobial, antibacterial, antifungal, and anticancer activities.
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Cite this article as:
Shimada Shigeru, Recent Advances in the Synthesis and Application of Bismuth-Containing Heterocyclic Compounds, Current Organic Chemistry 2011; 15 (5) . https://dx.doi.org/10.2174/138527211794518989
DOI https://dx.doi.org/10.2174/138527211794518989 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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