阿尔茨海默病脑肾上腺髓质素的表达

Title:Adrenomedullin Expression in Alzheimer's Brain

Volume: 13 Issue: 4

Author(s): Ana Patricia Fernandez, Julia Serrano Masa, Maria Atocha Guedan, Hunter S. Futch, Ricardo Martinez-Murillo

Affiliation:

关键词: 肾上腺髓质素；老年痴呆症；人类；神经保护作用；转基因小鼠。

摘要: Adrenomedullin (AM) is a potent vasodilator peptide highly expressed throughout the brain and originally isolated from pheochromocytoma cells. In addition to its vasoactive properties, AM is considered a neuromodulator that possesses antiapoptotic and antioxidant properties that suggest that this peptide can protect the brain from damage. In a previous study, we found that AM exerts a neuroprotective action in the brain and that this effect may be mediated by regulation of nitric oxide synthases, matrix metalloproteases, and inflammatory mediators. AM upregulation contributes to neuroprotection, but understanding the precise roles played by AM and its receptor (RAMP2) in neurodegenerative diseases including Alzheimer´s disease (AD), awaits further research. In search of Alzheimer´s biomarkers, the expression levels of peptides with endothelial vasodilatory action, including AM, were found to be significantly altered in mild AD or during pre-dementia stage of mild cognitive impairment. These studies concluded that ratio of AM or its precursor fragment mid-regional proAM in blood hold promise as diagnostic marker for AD. We are now presenting a study regarding the hypothesis that the AMRAMP2 system might be implicated in the pathophysiology of AD.

Cite this article as:

Ana Patricia Fernandez, Julia Serrano Masa, Maria Atocha Guedan, Hunter S. Futch, Ricardo Martinez-Murillo , Adrenomedullin Expression in Alzheimer's Brain, Current Alzheimer Research 2016; 13 (4) . https://dx.doi.org/10.2174/1567205013666160229112725