Abstract
The effects of the aqueous extract of Sesamum radiatum Schum & Tonn (ESera) were studied on the cardiovascular system of mammalians. ESera administered intravenously (6 x 10-4 g/kg b.w. - 5.7 x 10-2 g/kg b.w.), caused a decrease in the arterial blood arterial pressure (hypotension) in a dose-dependent manner (ED50 =0 1.3 x 10-2 g/kg b.w.). These effects induced by ESera were reversed in the presence of atropine at a concentration of 10-8 g/kg b.w. Our observations regarding the isolated heart of rat showed that the extract induced both negative inotropic and negative chronotropic effects. Similarly, the experimentation based on the isolated aorta obtained from guinea pig revealed that the extact decreased the basal tonus of this smooth muscle. These results suggest that ESera could act via cholinergic receptors. The effects of ESera could result from both cardiodepression and vasorelaxation mechanism.
Keywords: Sesamum radiatum aqueous extract (ESera), cardiovascular system, arterial blood pressure, cardiac muscle, aorta
Current Bioactive Compounds
Title: Action of the Aqueous Extract of Sesamum Radiatum Schum. & Tonn.(Pedaliaceae) on the Cardiovascular System of Mammalians: Hypotensive Effect
Volume: 2 Issue: 3
Author(s): Konan Brou Andre, Datte-Jacques Yao and Offoumou Atte Michel
Affiliation:
Keywords: Sesamum radiatum aqueous extract (ESera), cardiovascular system, arterial blood pressure, cardiac muscle, aorta
Abstract: The effects of the aqueous extract of Sesamum radiatum Schum & Tonn (ESera) were studied on the cardiovascular system of mammalians. ESera administered intravenously (6 x 10-4 g/kg b.w. - 5.7 x 10-2 g/kg b.w.), caused a decrease in the arterial blood arterial pressure (hypotension) in a dose-dependent manner (ED50 =0 1.3 x 10-2 g/kg b.w.). These effects induced by ESera were reversed in the presence of atropine at a concentration of 10-8 g/kg b.w. Our observations regarding the isolated heart of rat showed that the extract induced both negative inotropic and negative chronotropic effects. Similarly, the experimentation based on the isolated aorta obtained from guinea pig revealed that the extact decreased the basal tonus of this smooth muscle. These results suggest that ESera could act via cholinergic receptors. The effects of ESera could result from both cardiodepression and vasorelaxation mechanism.
Export Options
About this article
Cite this article as:
Brou Andre Konan, Yao Datte-Jacques and Atte Michel Offoumou, Action of the Aqueous Extract of Sesamum Radiatum Schum. & Tonn.(Pedaliaceae) on the Cardiovascular System of Mammalians: Hypotensive Effect, Current Bioactive Compounds 2006; 2 (3) . https://dx.doi.org/10.2174/1573407210602030263
DOI https://dx.doi.org/10.2174/1573407210602030263 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Potential Effect of Angiotensin II Receptor Blockade in Adipose Tissue and Bone
Current Pharmaceutical Design Toxicities of Immunosuppressive Treatment of Autoimmune Neurologic Diseases
Current Neuropharmacology Role of Salt and Potassium in Hypertension and the Associated Organ Damages
Current Hypertension Reviews Critical Illness in Obstetric Patients: Venous Thromboembolism in Pregnancy
Current Women`s Health Reviews Clozapine Safety, 40 Years Later
Current Drug Safety Role of Peroxynitrite in the Cardiovascular Dysfunction of Septic Shock
Current Vascular Pharmacology Phosphodiesterase 5 Inhibitors in the Treatment of Erectile Dysfunction
Current Pharmaceutical Design Discovery of New Cardiovascular Hormones for the Treatment of Congestive Heart Failure
Cardiovascular & Hematological Disorders-Drug Targets Acute and Sub-acute Oral Toxicity Assessment of a Standardized Polyherbal Preparation POL-6 in Rats
The Natural Products Journal β-Carboline Alkaloids: Biochemical and Pharmacological Functions
Current Medicinal Chemistry Bortezomib – First Therapeutic Proteasome Inhibitor for Cancer Therapy: A Review of Patent Literature
Recent Patents on Anti-Cancer Drug Discovery Therapy in Prion Diseases
Current Topics in Medicinal Chemistry Pathophysiology, Diagnosis and Clinical Management of Hepatorenal Syndrome: From Classic to New Drugs
Current Vascular Pharmacology What Restricts the Clinical Use of Nicotinic Acid?
Current Vascular Pharmacology Use of N-acetyl-cysteine to Prevent Nephrotoxicity Associated with Iodinated Contrast Agents
Current Drug Therapy Selective Serotonin Re-Uptake Inhibitors for the Treatment of Depression in Coronary Artery Disease and Chronic Heart Failure: Evidence for Pleiotropic Effects
Cardiovascular & Hematological Agents in Medicinal Chemistry Monoamine Oxidases: to Inhibit or Not to Inhibit
Mini-Reviews in Medicinal Chemistry Catheter-directed Thrombolysis <i>versus</i> Systemic Anticoagulation for Submassive Pulmonary Embolism: A Meta-Analysis
Current Cardiology Reviews The Concept of Titration can be Transposed to Fluid Management. But does is Change the Volumes? Randomised Trial on Pleth Variability Index During Fast-Track Colonic Surgery
Current Clinical Pharmacology Bioorganic Compounds Produced by the Fungus Monascus and their Use in Health Sciences and Medicine
Mini-Reviews in Organic Chemistry