Predominant Expression of rTERTb, an Inactive TERT Variant, in the Adult Rat Brain

Title: Predominant Expression of rTERTb, an Inactive TERT Variant, in the Adult Rat Brain

Volume: 13 Issue: 1

Author(s): R. Kaneko, S. Esumi, T. Yagi and T. Hirabayashi

Affiliation:

Keywords: Alternative splicing, Telomerase, TERT, Brain development, Rattus norvegicus

Abstract: The full-length and four alternatively spliced variant mRNA transcripts of rat TERT were identified. One of the variant, rTERTb, was predominantly expressed during brain development in accordance with the decrease in telomerase activity. The rTERTb mRNA encoded an inactive truncated protein. Alternative splicing of TERT may be important during brain development.

Cite this article as:

Kaneko R., Esumi S., Yagi T. and Hirabayashi T., Predominant Expression of rTERTb, an Inactive TERT Variant, in the Adult Rat Brain, Protein & Peptide Letters 2006; 13 (1) . https://dx.doi.org/10.2174/092986606774502108