Pattern of Positions Sensitive to Mutations in Human Haemoglobin α-Chain

N.      Gao; S.      Yan; G.      Wu

doi:10.2174/092986606774502090

Abstract

In this study, we used the distribution rank, which has been developed by us over the past several years, to quantify 134 mutations in the human hemoglobin α-chain in order to gain an insight into the general pattern in mutations. The results suggest that the pattern presented by distribution rank can approximately estimate the positions that are sensitive to mutations in human hemoglobin α-chain.

Keywords: Human hemoglobin a-chain, mutation, probability

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Protein & Peptide Letters

Title: Pattern of Positions Sensitive to Mutations in Human Haemoglobin α-Chain

Volume: 13 Issue: 1

Author(s): N. Gao, S. Yan and G. Wu

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Keywords: Human hemoglobin a-chain, mutation, probability

Abstract: In this study, we used the distribution rank, which has been developed by us over the past several years, to quantify 134 mutations in the human hemoglobin α-chain in order to gain an insight into the general pattern in mutations. The results suggest that the pattern presented by distribution rank can approximately estimate the positions that are sensitive to mutations in human hemoglobin α-chain.

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Gao N., Yan S. and Wu G., Pattern of Positions Sensitive to Mutations in Human Haemoglobin α-Chain, Protein & Peptide Letters 2006; 13 (1) . https://dx.doi.org/10.2174/092986606774502090