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Inflammation & Allergy - Drug Targets (Discontinued)

Editor-in-Chief

ISSN (Print): 1871-5281
ISSN (Online): 2212-4055

New Insights into HLA-G and Inflammatory Diseases

Author(s): Roberta Rizzo, Daria Bortolotti, Olavio R. Baricordi and Enrico Fainardi

Volume 11, Issue 6, 2012

Page: [448 - 463] Pages: 16

DOI: 10.2174/187152812803590037

Price: $65

Abstract

Human leucocyte antigen-G (HLA-G) is a non-classical HLA class I molecule with an important role at the fetus-maternal interface, preventing fetus recognition and abortion. The role of HLA-G as an immune-modulatory and anti-inflammatory molecule has led to investigate its role in pathological conditions. In these years, HLA-G has been shown to have an important implication in inflammatory pathologies. The focus of this review is to up-date the scientific knowledge on the expression of HLA-G molecules in inflammatory conditions.

Keywords: HLA-G, immunity, immune cells, inflammation, pathology, regulation, Human leucocyte antigen-G, anti-inflammatory, HLA-G typing, Allergic disorders


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