ABCB1, SLCO1B1 and UGT1A1 Gene Polymorphisms Are Associated with Toxicity Line Irinotecan

Title: ABCB1, SLCO1B1 and UGT1A1 Gene Polymorphisms Are Associated with Toxicity Line Irinotecan

Volume: 1 Issue: 1

Author(s): Katrin E. Rhodes, Wu Zhang, Dongyun Yang, Oliver A. Press, Michael Gordon, Daniel Vallbohmer, Anne M. Schultheis, Georg Lurje, Robert D. Ladner, William Fazzone, Heinz-Josef Lenz and Syma Iqbal

Affiliation:

Keywords: Polymorphisms, colorectal cancer, toxicity, irinotecan

Abstract: We tested specific gene polymorphisms known to be involved in the irinotecan (CPT-11) metabolic pathway. The combination of at least one SLCO1B1 521 T allele, one ABCB1 1236 C allele and one UGT1A1*28 variant 7 repeat demonstrated a statistically significant association with Grade 3/4 toxicities in metastatic colorectal cancer patients.

Cite this article as:

Rhodes E. Katrin, Zhang Wu, Yang Dongyun, Press A. Oliver, Gordon Michael, Vallbohmer Daniel, Schultheis M. Anne, Lurje Georg, Ladner D. Robert, Fazzone William, Lenz Heinz-Josef and Iqbal Syma, ABCB1, SLCO1B1 and UGT1A1 Gene Polymorphisms Are Associated with Toxicity Line Irinotecan, Drug Metabolism Letters 2007; 1 (1) . https://dx.doi.org/10.2174/187231207779814328