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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Review Article

A Review of AEG-1 Oncogene Regulating MicroRNA Expression in Colon Cancer Progression

Author(s): Sarubala Malayaperumal*, Sushmitha Sriramulu, Ganesan Jothimani, Antara Banerjee and Surajit Pathak*

Volume 21, Issue 1, 2021

Published on: 18 June, 2020

Page: [27 - 34] Pages: 8

DOI: 10.2174/1871530320666200618104116

Price: $65

Abstract

MicroRNAs are a class of small non-coding RNAs that perform a crucial function in posttranscriptional gene regulation. Dysregulation of these microRNAs is associated with many types of cancer progression. In tumorigenesis, downregulated microRNAs might function as a tumour suppressor by repressing oncogenes, whereas overexpressed miRs might function as oncogenes by suppressing tumour suppressor. Similarly, Metadherin (also known as AEG-1/ LYRIC), is an oncogene, the levels of which are found to be very high in various cancers and play a crucial role in the proliferation of cells and invasion. Our review focuses on the study, which shows the alteration of microRNA expression profile and suppression of carcinogenesis when MTDH/AEG-1 is targeted. It summarises the studies where downregulation and upregulation of AEG-1 and microRNAs, respectively, alter the biological functions of the cell, such as proliferation and apoptosis. Studies have reported that AEG-1 can be direct or indirect target of microRNA, which could provide a new-insight to know the underlying molecular mechanism and might contribute to the progress of new therapeutic strategies for the disease.

Keywords: Colorectal cancer, oncogene, microRNA, AEG-1/MTDH/LYRIC, biomarker.

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