Effect of Common NAT2 Variant Alleles in the Acetylation of the Major Clonazepam Metabolite, 7-minoclonazepam

Title: Effect of Common NAT2 Variant Alleles in the Acetylation of the Major Clonazepam Metabolite, 7-minoclonazepam

Volume: 1 Issue: 1

Author(s): M. Olivera, C. Martinez, G. Gervasini, J. A. Carrillo, S. Ramos, J. Benitez, E. Garcia-Martin and J. A. G. Agundez

Affiliation:

Keywords: NAT2, acetylation, polymorphism, pharmacogenomics

Abstract: We investigated the role of NAT2 on clonazepam acetylation, using transiently expressed human NAT2 alleles. The NAT25*B and the NAT2*6A variant alleles cause a 20 and 22-fold reduction in the Vmax, respectively. We conclude that NAT2 is responsible for 7-aminoclonazepam acetylation and that NAT2 gene polymorphisms impair such metabolic pathway.

Cite this article as:

Olivera M., Martinez C., Gervasini G., Carrillo A. J., Ramos S., Benitez J., Garcia-Martin E. and G. Agundez A. J., Effect of Common NAT2 Variant Alleles in the Acetylation of the Major Clonazepam Metabolite, 7-minoclonazepam, Drug Metabolism Letters 2007; 1 (1) . https://dx.doi.org/10.2174/187231207779814283