CXCR4 Receptor as a Promising Target for Oncolytic Drugs

Title: CXCR4 Receptor as a Promising Target for Oncolytic Drugs

Volume: 8 Issue: 11

Author(s): Yan Lavrovsky, Yan A. Ivanenkov, Konstantin V. Balakin, Darya A. Medvedeva and Alexandre V. Ivachtchenko

Affiliation:

Keywords: Chemokine, chemokine receptor, CXCR4, CXCL12, SDF-1, tumor, cancer, drugs, inhibitors, antagonists

Abstract: There has been considerable in vivo evidence that chemokine receptor CXCR4 and its endogenous ligand CXCL12 modulate some important physiological and pathophysiological processes, including cancer metastasis, angiogenesis, invasion, growth and progression. In this review we elucidate key aspects of CXCL12-CXCR4 signaling system with emphasis on peptide-based and small-molecule CXCR4 inhibitors.

Cite this article as:

Lavrovsky Yan, Ivanenkov A. Yan, Balakin V. Konstantin, Medvedeva A. Darya and Ivachtchenko V. Alexandre, CXCR4 Receptor as a Promising Target for Oncolytic Drugs, Mini-Reviews in Medicinal Chemistry 2008; 8 (11) . https://dx.doi.org/10.2174/138955708785909907