Abstract
Naproxen or 2-(6-methoxy naphthalen-2-yl)propionic acid participated in trifluoroacetic anhydride/ phosphoric acid mediated C-C bond forming reaction in a regioselective fashion when treated with a variety of arene or heteroarene under a solvent-free condition affording novel 1-aryl/heteroaryl substituted 2-(6-methoxy naphthalen-2-yl)propan-1-ones in good yields.
Keywords: Naproxen, acylation, trifluoroacetic anhydride, phosphoric acid
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