Abstract
The sol-gel process provides a robust and versatile technology for the immobilization of biologicals. A wide range of inorganic, composites and hybrid materials can be prepared to encapsulate molecular drugs, proteins, antibodies/antigens, enzymes, nucleic acids, prokaryotic and eukaryotic cells into bulk gels, particles and films. This review describes the applications of sol-gel encapsulation relevant to medicinal chemistry focusing on the recent development of biosensors as well as systems for production, screening and delivery of bioactive compounds and biomaterials.
Keywords: Bioreactors, Biosensors, Delivery, Drug, Encapsulation, Sol-gel, Tissue engineering.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:Sol-gel Encapsulation of Biomolecules and Cells for Medicinal Applications
Volume: 15 Issue: 3
Author(s): Xiaolin Wang, Nada Ben Ahmed, Gisela S. Alvarez, Maria V. Tuttolomondo, Christophe Helary, Martin F. Desimone and Thibaud Coradin
Affiliation:
Keywords: Bioreactors, Biosensors, Delivery, Drug, Encapsulation, Sol-gel, Tissue engineering.
Abstract: The sol-gel process provides a robust and versatile technology for the immobilization of biologicals. A wide range of inorganic, composites and hybrid materials can be prepared to encapsulate molecular drugs, proteins, antibodies/antigens, enzymes, nucleic acids, prokaryotic and eukaryotic cells into bulk gels, particles and films. This review describes the applications of sol-gel encapsulation relevant to medicinal chemistry focusing on the recent development of biosensors as well as systems for production, screening and delivery of bioactive compounds and biomaterials.
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Cite this article as:
Wang Xiaolin, Ahmed Ben Nada, Alvarez S. Gisela, Tuttolomondo V. Maria, Helary Christophe, Desimone F. Martin and Coradin Thibaud, Sol-gel Encapsulation of Biomolecules and Cells for Medicinal Applications, Current Topics in Medicinal Chemistry 2015; 15 (3) . https://dx.doi.org/10.2174/1568026614666141229112734
DOI https://dx.doi.org/10.2174/1568026614666141229112734 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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