The Role of T and B Cells in Atherosclerosis: Potential Clinical Implications

Title: The Role of T and B Cells in Atherosclerosis: Potential Clinical Implications

Volume: 17 Issue: 37

Author(s): I. E. Dumitriu and J. C. Kaski

Affiliation:

Keywords: Adaptive immune response, T cells, B cells, atherosclerosis, metallo-proteinases (MMPs), acute coronary syndrome (ACS), macrophages, monoclonal antibody, rheumatoid arthritis, systemic lupus erythematosus

Abstract: The chronic inflammation process that characterises atherosclerosis involves both the innate and adaptive arms of the immune system. Several lines of evidence have recently highlighted pivotal roles for T and B lymphocytes – cells that belong to the adaptive immune system – in the development and progression of atherosclerosis. In this review, we summarise the current knowledge on the roles of adaptive immune responses in atherosclerosis and present our views on how a better understanding of these immune mechanisms could shape future therapies to slow down or even prevent this disease.

Cite this article as:

E. Dumitriu I. and C. Kaski J., The Role of T and B Cells in Atherosclerosis: Potential Clinical Implications, Current Pharmaceutical Design 2011; 17 (37) . https://dx.doi.org/10.2174/138161211798764834