Abstract
Hydrogen sulfide (H2S), as one of the endogenous gasotransmitters, has shown great potential in treating cardiovascular diseases (CVDs). H2S plays a protective role in CVDs by removing reactive oxygen species (ROS), promoting vasodilation, inhibiting myocardial hypertrophy, preventing thrombosis, and protecting mitochondria. However, there still exist some problems for H2S as drugs such as challenging delivery, uncontrollable release rate, and other drug developability issues. Addressing these problems, the prodrug strategy shows great potential. Therefore, a key issue on the H2S-based therapeutics is developing appropriate H2S prodrugs. In this review, we mainly discussed the mechanism of H2S against CVDs and reviewed the cardiovascular effects of current H2S prodrugs.
Keywords: Hydrogen sulfide (H2S), Gasotransmitter, Cardiovascular diseases (CVDs), H2S prodrug, Thrombosis, Astrocytes.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:Recent Development of Hydrogen Sulfide Therapeutics in the Treatment of Cardiovascular Diseases
Volume: 21 Issue: 24
Author(s): Wen Peng, Weiwei Guo*Yueqing Zheng*
Affiliation:
- Academic Institute of Pharmaceutical Science China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009,China
- Academic Institute of Pharmaceutical Science China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009,China
Keywords: Hydrogen sulfide (H2S), Gasotransmitter, Cardiovascular diseases (CVDs), H2S prodrug, Thrombosis, Astrocytes.
Abstract: Hydrogen sulfide (H2S), as one of the endogenous gasotransmitters, has shown great potential in treating cardiovascular diseases (CVDs). H2S plays a protective role in CVDs by removing reactive oxygen species (ROS), promoting vasodilation, inhibiting myocardial hypertrophy, preventing thrombosis, and protecting mitochondria. However, there still exist some problems for H2S as drugs such as challenging delivery, uncontrollable release rate, and other drug developability issues. Addressing these problems, the prodrug strategy shows great potential. Therefore, a key issue on the H2S-based therapeutics is developing appropriate H2S prodrugs. In this review, we mainly discussed the mechanism of H2S against CVDs and reviewed the cardiovascular effects of current H2S prodrugs.
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Cite this article as:
Peng Wen , Guo Weiwei *, Zheng Yueqing*, Recent Development of Hydrogen Sulfide Therapeutics in the Treatment of Cardiovascular Diseases, Current Topics in Medicinal Chemistry 2021; 21 (24) . https://dx.doi.org/10.2174/1568026621666210831163817
DOI https://dx.doi.org/10.2174/1568026621666210831163817 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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