Generic placeholder image

Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Heterocyclic Analogues as Kinase Inhibitors: A Focus Review

Author(s): Vikas Sharma, Raj Kamal and Vipin Kumar*

Volume 17, Issue 22, 2017

Page: [2482 - 2494] Pages: 13

DOI: 10.2174/1568026617666170307113744

Price: $65

Abstract

Role of kinase inhibitors in various diseases is well established and discovery of imatinib opens up new paradigms in kinase inhibition. Furthermore, presence of heterocyclic moiety in a kinase inhibitor seems to be essential now. However, the potential of a single heterocyclic moiety was discussed in variety of reviews but a focus review considering the potential of different heterocyclic moieties is unavailable. Based on this, we classify prospective kinase inhibitors on the basis of number of heterocyclic moieties present and summarize the prospective kinase inhibitors. Finally, important key points, current challenges and future prospects of kinase inhibitors are also discussed.

Keywords: Kinase, imatinib, heterocyclic, inhibitor, moieties, sorafexib

Graphical Abstract


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy