Stability of Synthetic Exendin-4 in Human Plasma In Vitro

Title: Stability of Synthetic Exendin-4 in Human Plasma In Vitro

Volume: 14 Issue: 1

Author(s): Jie Chen, Ling Yu, Liping Wang, Xuexun Fang, Li Li and Wei Li

Affiliation:

Keywords: Synthetic exendin-4, Glucagon-like peptide, Stability, Dipeptidyl peptidase-IV(DPP- V)

Abstract: Sites of exendin-4 that that are relatively susceptible to degradation in plasma were identified with the aim of providing information for designing new exendin-4 analogues. The stability of exendin-4 in human plasma was evaluated in vitro. The results showed that the peptide was slowly degraded with a half-life of 9.57 h and the principal cleavage sites are between Thr5 and Phe6, Phe6 and Thr7, and Thr7 and Ser8 of the N-terminus region of exendin-4.

Cite this article as:

Chen Jie, Yu Ling, Wang Liping, Fang Xuexun, Li Li and Li Wei, Stability of Synthetic Exendin-4 in Human Plasma In Vitro, Protein & Peptide Letters 2007; 14 (1) . https://dx.doi.org/10.2174/092986607779117272