Small Molecule Inhibitors of Protein Kinases in Cancer- How to Overcome Resistance

Title: Small Molecule Inhibitors of Protein Kinases in Cancer- How to Overcome Resistance

Volume: 6 Issue: 10

Author(s): R. Griffith, M. N. Brown, A. McCluskey and L. K. Ashman

Affiliation:

Keywords: Anti-cancer agents, protein kinase inhibitors, drug design, active kinase conformation, nactive kinase conformation, selectivity, inactive kinase conformation

Abstract: Small molecule protein kinase inhibitors show great promise as anti-cancer agents, however, de novo and acquired resistance present problems. These are reviewed and illustrated using the receptor tyrosine kinase, KIT, as an example. Emerging solutions are presented, such as targeting active kinase conformations.

Cite this article as:

Griffith R., N. Brown M., McCluskey A. and K. Ashman L., Small Molecule Inhibitors of Protein Kinases in Cancer- How to Overcome Resistance, Mini-Reviews in Medicinal Chemistry 2006; 6 (10) . https://dx.doi.org/10.2174/138955706778560184