Recombinant Factor VIIA, its Clinical Properties, and the Tissue Factor Pathway of Coagulation

Title: Recombinant Factor VIIA, its Clinical Properties, and the Tissue Factor Pathway of Coagulation

Volume: 6 Issue: 10

Author(s): Timothy J. Bosinski and Ali A. El Solh

Affiliation:

Keywords: Recombinant factor VIIa, tissue factor, hemostasis, coagulation

Abstract: Recombinant factor VIIa (rFVIIa) is a synthetic coagulation protease that is structurally similar to humanderived plasma FVIIa. Pharmacologic doses of rFVIIa have been shown to enhance thrombin generation and assist in forming stable fibrin plugs at the site of injury. Recombinant factor VIIa appears to emerge as a valuable treatment alternative for the treatment of bleeding episodes and for achieving hemostasis post surgery in those with bleeding disorders.

Cite this article as:

J. Bosinski Timothy and A. El Solh Ali, Recombinant Factor VIIA, its Clinical Properties, and the Tissue Factor Pathway of Coagulation, Mini-Reviews in Medicinal Chemistry 2006; 6 (10) . https://dx.doi.org/10.2174/138955706778560201