Abstract
Photodynamic therapy (PDT), in which stained cells are damaged by light in the presence of oxygen, is now widely used for tumor destruction. Photogenerated singlet oxygen and reactive oxygen species cause oxidative stress and cell death. The potential ROS sensors and following intracellular processes leading to cell death are considered. The cell death mode (necrosis or apoptosis) is shown to be controlled not only by PDT parameters (irradiation intensity, intracellular photosensitizer localization and its concentration) but also by signal transduction processes. Calcium and adenylate cyclase signaling pathways, receptor tyrosine kinases, MAP kinases, phosphatidylinositol 3-kinase pathway, various protein kinases and phosphatases, transcription factors, ceramide, NO, the plasma membrane, mitochondria and endoplasmic reticulum are involved in the cell response to photodynamic injury and following death. Combination of PDT and pharmacological modulators of signaling pathways can either enhance injury of malignant cells, or protect surrounding normal cells.
Keywords: Cell death, apoptosis, necrosis, signaling pathways, photodynamic therapy
Current Signal Transduction Therapy
Title: Signal Transduction and Photodynamic Therapy
Volume: 3 Issue: 1
Author(s): Anatoly B. Uzdensky
Affiliation:
Keywords: Cell death, apoptosis, necrosis, signaling pathways, photodynamic therapy
Abstract: Photodynamic therapy (PDT), in which stained cells are damaged by light in the presence of oxygen, is now widely used for tumor destruction. Photogenerated singlet oxygen and reactive oxygen species cause oxidative stress and cell death. The potential ROS sensors and following intracellular processes leading to cell death are considered. The cell death mode (necrosis or apoptosis) is shown to be controlled not only by PDT parameters (irradiation intensity, intracellular photosensitizer localization and its concentration) but also by signal transduction processes. Calcium and adenylate cyclase signaling pathways, receptor tyrosine kinases, MAP kinases, phosphatidylinositol 3-kinase pathway, various protein kinases and phosphatases, transcription factors, ceramide, NO, the plasma membrane, mitochondria and endoplasmic reticulum are involved in the cell response to photodynamic injury and following death. Combination of PDT and pharmacological modulators of signaling pathways can either enhance injury of malignant cells, or protect surrounding normal cells.
Export Options
About this article
Cite this article as:
Uzdensky B. Anatoly, Signal Transduction and Photodynamic Therapy, Current Signal Transduction Therapy 2008; 3 (1) . https://dx.doi.org/10.2174/157436208783334277
DOI https://dx.doi.org/10.2174/157436208783334277 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Quinoline as a Privileged Scaffold in Cancer Drug Discovery
Current Medicinal Chemistry ErbB Targeted Drugs and Angiogenesis
Current Vascular Pharmacology Neuropilin-1 (NRP-1) and Magnetic Nanoparticles, a Potential Combination for Diagnosis and Therapy of Gliomas
Current Pharmaceutical Design The Death Pathways in the Neonatal Gut
Current Pediatric Reviews Lipoxygenase (LOX) Pathway: A Promising Target to Combat Cancer
Current Pharmaceutical Design Fungal Biofilm – A Real Obstacle Against an Efficient Therapy: Lessons from Candida
Current Topics in Medicinal Chemistry Biomedical Applications of Superparamagnetic Nanoparticles in Molecular Scale
Current Organic Chemistry Clinico-Pathologic and Biologic Predictors of EGFR Inhibitors Activity and Efficacy in Lung and in Colorectal Cancer
Current Signal Transduction Therapy Methylation of ZNF331 Promotes Cell Invasion and Migration in Human Esophageal Cancer
Current Protein & Peptide Science Breast Cancer Resistance Protein: A Potential Therapeutic Target for Cancer
Current Drug Targets Dietary Polyphenols for Prostate Cancer Therapy
Current Bioactive Compounds A Systematic Review of Genes Involved in the Inverse Resistance Relationship Between Cisplatin and Paclitaxel Chemotherapy: Role of BRCA1
Current Cancer Drug Targets A Review of the Use of Stents for Palliation of Esophageal and Lung Cancer
Current Cancer Therapy Reviews Medication-Induced Acute Abdominal Pain: Evaluation with CT Imaging
Current Medical Imaging Prognostic Value of MiRNAs in Patients with Laryngeal Cancer: A Systematic Review and Meta-Analysis
Current Cancer Drug Targets Recent Clinical Trials in Non-Small Cell Lung Cancer
Current Cancer Therapy Reviews Editorial from Guest Editor. Chronic Cough
Current Respiratory Medicine Reviews Classical Inhibitors of NOX NAD(P)H Oxidases Are Not Specific
Current Drug Metabolism Berberine Exerts Anti-cancer Activity by Modulating Adenosine Monophosphate- Activated Protein Kinase (AMPK) and the Phosphatidylinositol 3-Kinase/ Protein Kinase B (PI3K/AKT) Signaling Pathways
Current Pharmaceutical Design Reactive Oxygen Species in Cancer Biology and Anticancer Therapy
Current Medicinal Chemistry